PMID- 17855395
OWN - NLM
STAT- MEDLINE
DCOM- 20071126
LR  - 20181113
IS  - 1362-4962 (Electronic)
IS  - 0305-1048 (Print)
IS  - 0305-1048 (Linking)
VI  - 35
IP  - 18
DP  - 2007
TI  - Novel rapidly evolving hominid RNAs bind nuclear factor 90 and display 
      tissue-restricted distribution.
PG  - 6249-58
AB  - Nuclear factor 90 (NF90) is a double-stranded RNA-binding protein implicated in 
      multiple cellular functions, but with few identified RNA partners. Using in vivo 
      cross-linking followed by immunoprecipitation, we discovered a family of small 
      NF90-associated RNAs (snaR). These highly structured non-coding RNAs of 
      approximately 117 nucleotides are expressed in immortalized human cell lines of 
      diverse lineages. In human tissues, they are abundant in testis, with minor 
      distribution in brain, placenta and some other organs. Two snaR subsets were 
      isolated from human 293 cells, and additional species were found by bioinformatic 
      analysis. Their genes often occur in multiple copies arranged in two inverted 
      regions of tandem repeats on chromosome 19. snaR-A is transcribed by RNA 
      polymerase III from an intragenic promoter, turns over rapidly, and shares 
      sequence identity with Alu RNA and two potential piRNAs. It interacts with NF90's 
      double-stranded RNA-binding motifs. snaR orthologs are present in chimpanzee but 
      not other mammals, and include genes located in the promoter of two chorionic 
      gonadotropin hormone genes. snaRs appear to have undergone accelerated evolution 
      and differential expansion in the great apes.
FAU - Parrott, Andrew M
AU  - Parrott AM
AD  - Department of Biochemistry and Molecular Biology, New Jersey Medical School, 
      UMDNJ, 185 South Orange Ave., P. O. Box 1709, Newark, NJ 07101-1709, USA.
FAU - Mathews, Michael B
AU  - Mathews MB
LA  - eng
GR  - R01 AI034552/AI/NIAID NIH HHS/United States
GR  - AI034552/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20070913
PL  - England
TA  - Nucleic Acids Res
JT  - Nucleic acids research
JID - 0411011
RN  - 0 (Nuclear Factor 90 Proteins)
RN  - 0 (RNA, Untranslated)
RN  - EC 2.7.7.6 (RNA Polymerase III)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Cell Line
MH  - *Evolution, Molecular
MH  - Humans
MH  - Molecular Sequence Data
MH  - Nuclear Factor 90 Proteins/*metabolism
MH  - Pan troglodytes/genetics
MH  - RNA Polymerase III/metabolism
MH  - RNA, Untranslated/chemistry/*genetics/*metabolism
MH  - Sequence Alignment
MH  - Tissue Distribution
PMC - PMC2094060
EDAT- 2007/09/15 09:00
MHDA- 2007/12/06 09:00
PMCR- 2007/09/13
CRDT- 2007/09/15 09:00
PHST- 2007/09/15 09:00 [pubmed]
PHST- 2007/12/06 09:00 [medline]
PHST- 2007/09/15 09:00 [entrez]
PHST- 2007/09/13 00:00 [pmc-release]
AID - gkm668 [pii]
AID - 10.1093/nar/gkm668 [doi]
PST - ppublish
SO  - Nucleic Acids Res. 2007;35(18):6249-58. doi: 10.1093/nar/gkm668. Epub 2007 Sep 
      13.