PMID- 17855447
OWN - NLM
STAT- MEDLINE
DCOM- 20080122
LR  - 20211203
IS  - 0964-6906 (Print)
IS  - 0964-6906 (Linking)
VI  - 16
IP  - 23
DP  - 2007 Dec 1
TI  - Common genetic variation in calpain-10 gene (CAPN10) and diabetes risk in a 
      multi-ethnic cohort of American postmenopausal women.
PG  - 2960-71
AB  - Calpain-10 (CAPN10) protein may play a role in glucose metabolisms, pancreatic 
      beta-cell insulin secretion and thermogenesis. Emerging evidence has implicated a 
      role of CAPN10 genetic variants in the risk of type 2 diabetes mellitus (T2DM). 
      Previous association studies, however, have focussed only on several variants 
      initially reported and provided inconsistent results. We conducted a large nested 
      case-control study to comprehensively investigate the associations between common 
      variations in CAPN10 gene and T2DM risk among postmenopausal women aged 50-79 
      years from the Women's Health Initiative Observational Study. After comprehensive 
      screening in 244 randomly chosen control samples (n = 61 for each of four ethnic 
      groups), we selected a total of 12 tagging single nucleotide polymorphisms 
      (tSNPs) spanning 91 kb in CAPN10 and genotyped them in 1543 diabetes cases and 
      2132 matched controls (including 968 cases and 968 controls for whites, 366 and 
      732 for blacks, 152 and 303 for Hispanics and 98 and 195 for Asian/Pacific 
      Islanders). There were no significant associations between any individual tSNP 
      and T2DM, within either the full study sample or any specific ethnic group. Nor 
      was there any evidence of association between common CAPN10 haplotypes and 
      diabetes risk (global tests for differences in risk were P = 0.31 for overall 
      common haplotypes, P = 0.44 for haplotypes in block 1 and P = 0.37 for haplotypes 
      in block 2). In conclusion, we did not observe any significant associations of 
      the common SNPs or haplotypes across the CAPN10 gene with diabetes risk in our 
      large and ethnically diverse cohort of postmenopausal women.
FAU - Song, Yiqing
AU  - Song Y
AD  - Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 
      Boston , MA 02215, USA.
FAU - You, Nai-chieh
AU  - You NC
FAU - Hsu, Yi-Hsiang
AU  - Hsu YH
FAU - Sul, James
AU  - Sul J
FAU - Wang, Lin
AU  - Wang L
FAU - Tinker, Lesley
AU  - Tinker L
FAU - Eaton, Charles B
AU  - Eaton CB
FAU - Liu, Simin
AU  - Liu S
LA  - eng
GR  - R01 DK062290/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20070912
PL  - England
TA  - Hum Mol Genet
JT  - Human molecular genetics
JID - 9208958
RN  - EC 3.4.22.- (Calpain)
RN  - EC 3.4.22.- (calpain 10)
SB  - IM
MH  - Aged
MH  - Calpain/*genetics
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*etiology/*genetics
MH  - Ethnicity/genetics
MH  - Female
MH  - Genetic Variation
MH  - Haplotypes
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Menopause
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Risk Factors
MH  - United States
EDAT- 2007/09/15 09:00
MHDA- 2008/01/23 09:00
CRDT- 2007/09/15 09:00
PHST- 2007/09/15 09:00 [pubmed]
PHST- 2008/01/23 09:00 [medline]
PHST- 2007/09/15 09:00 [entrez]
AID - ddm256 [pii]
AID - 10.1093/hmg/ddm256 [doi]
PST - ppublish
SO  - Hum Mol Genet. 2007 Dec 1;16(23):2960-71. doi: 10.1093/hmg/ddm256. Epub 2007 Sep 
      12.