PMID- 1786526
OWN - NLM
STAT- MEDLINE
DCOM- 19920323
LR  - 20190613
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 563
IP  - 1-2
DP  - 1991 Nov 1
TI  - Angiotensin II-induced noradrenaline release from anterior hypothalamus in 
      conscious rats: a brain microdialysis study.
PG  - 137-41
AB  - Interaction with aminergic transmitter substances has been implicated in the 
      central actions of angiotensin II (ANG II). We used the novel technique of brain 
      microdialysis in conscious rats to investigate whether ANG II influences the 
      release of endogenous catecholamines (CA) from the anterior hypothalamus (AH). 
      Intracerebroventricular (i.c.v.) administration of ANG II (1 ng and 100 ng) 
      increased mean arterial pressure. ANG II at 1 ng had no effect on the release of 
      noradrenaline (NA) from the AH but ANG II at 100 ng significantly increased NA 
      release. Intracerebroventricular pretreatment with the ANG II-receptor antagonist 
      sarilesin (Sar1, Ile8-ANG II; 3 micrograms) prevented the ANG II-induced NA 
      release. The release of the intraneuronal NA and dopamine (DA) metabolites 
      3,4-dihydroxyphenylethyl glycol (DOPEG) and 3,4-dihydroxyphenylacetic acid 
      (DOPAC) from the AH was not altered by i.c.v. ANG II. Our results provide the 
      first in vivo evidence for NA release from the hypothalamus induced by 
      periventricular ANG II receptor stimulation. They support the hypothesis that 
      hypothalamic noradrenergic mechanisms are involved in the central actions of this 
      peptide.
FAU - Qadri, F
AU  - Qadri F
AD  - Department of Pharmacology, University of Heidelberg, F.R.G.
FAU - Badoer, E
AU  - Badoer E
FAU - Stadler, T
AU  - Stadler T
FAU - Unger, T
AU  - Unger T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 102-32-9 (3,4-Dihydroxyphenylacetic Acid)
RN  - 11128-99-7 (Angiotensin II)
RN  - 534-82-7 (Methoxyhydroxyphenylglycol)
RN  - 9088-01-1 (1-Sarcosine-8-Isoleucine Angiotensin II)
RN  - UEH9K539KJ (3,4-dihydroxyphenylglycol)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - 1-Sarcosine-8-Isoleucine Angiotensin II/pharmacology
MH  - 3,4-Dihydroxyphenylacetic Acid/metabolism
MH  - Angiotensin II/*pharmacology
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Brain Chemistry/*drug effects
MH  - Dialysis
MH  - Heart Rate/drug effects
MH  - Hypothalamus, Anterior/drug effects/*metabolism
MH  - Injections, Intraventricular
MH  - Male
MH  - Methoxyhydroxyphenylglycol/analogs & derivatives/metabolism
MH  - Norepinephrine/*metabolism
MH  - Rats
MH  - Rats, Inbred Strains
EDAT- 1991/11/01 00:00
MHDA- 1991/11/01 00:01
CRDT- 1991/11/01 00:00
PHST- 1991/11/01 00:00 [pubmed]
PHST- 1991/11/01 00:01 [medline]
PHST- 1991/11/01 00:00 [entrez]
AID - 0006-8993(91)91526-7 [pii]
AID - 10.1016/0006-8993(91)91526-7 [doi]
PST - ppublish
SO  - Brain Res. 1991 Nov 1;563(1-2):137-41. doi: 10.1016/0006-8993(91)91526-7.