PMID- 1786702
OWN - NLM
STAT- MEDLINE
DCOM- 19920326
LR  - 20191028
IS  - 0739-7240 (Print)
IS  - 0739-7240 (Linking)
VI  - 8
IP  - 4
DP  - 1991 Oct
TI  - Neuroendocrine regulation of growth hormone secretion in sheep. IV. Central and 
      peripheral cholecystokinin.
PG  - 555-63
AB  - The result of alterations in the levels of CCK, in the blood and in the 
      cerebrospinal fluid, on the functioning of the growth hormone axis has been 
      examined in sheep. Male Coopworth sheep of about 40 kg liveweight were given 
      various doses of CCK either intracerebroventricularly (icv) or intravenously 
      (iv). Other similar sheep were given various doses of a CCK antagonist 
      (loxiglumide) by the same routes. Bolus iv administration of either 35 micrograms 
      or 200 micrograms of CCK had no effect on plasma GH levels. When given icv, 
      however, CCK resulted in a marked (P less than 0.01) prolonged depression in 
      plasma GH levels. The decrease in GH secretion could be partially attenuated by 
      concurrent administration of loxiglumide, but was completely unaffected by 
      concurrent administration of antisomatostatin serum icv. Loxiglumide alone had no 
      effect on plasma GH levels when given at up to 200 micrograms icv, but 
      intravenous administration of 8 mg of the CCK antagonist resulted in an increase 
      in plasma GH concentrations (P less than 0.05). Plasma levels of somatostatin, 
      glucose and cortisol were unaffected by both icv and iv administration of CCK. 
      These results show that CCK can have a strong GH-inhibiting effect in the brain. 
      Furthermore, this effect seems to be independent of hypothalamic somatostatin, 
      suggesting another GH-inhibiting system exists.
FAU - Spencer, G S
AU  - Spencer GS
AD  - Ruakura Agricultural Centre, Hamilton, New Zealand.
FAU - Berry, C
AU  - Berry C
FAU - Johnston, S
AU  - Johnston S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Domest Anim Endocrinol
JT  - Domestic animal endocrinology
JID - 8505191
RN  - 0 (Immune Sera)
RN  - 77MPX3N42I (loxiglumide)
RN  - 9002-72-6 (Growth Hormone)
RN  - 9011-97-6 (Cholecystokinin)
RN  - EPL8W5565D (Proglumide)
SB  - IM
MH  - Animals
MH  - Cholecystokinin/administration & dosage/antagonists & inhibitors/*pharmacology
MH  - Growth Hormone/immunology/*metabolism
MH  - Immune Sera/administration & dosage/immunology
MH  - Injections, Intravenous/veterinary
MH  - Injections, Intraventricular/veterinary
MH  - Male
MH  - Neurosecretory Systems/*physiology
MH  - Proglumide/administration & dosage/analogs & derivatives/pharmacology
MH  - Sheep/*physiology
EDAT- 1991/10/01 00:00
MHDA- 1991/10/01 00:01
CRDT- 1991/10/01 00:00
PHST- 1991/10/01 00:00 [pubmed]
PHST- 1991/10/01 00:01 [medline]
PHST- 1991/10/01 00:00 [entrez]
AID - 0739-7240(91)90025-F [pii]
AID - 10.1016/0739-7240(91)90025-f [doi]
PST - ppublish
SO  - Domest Anim Endocrinol. 1991 Oct;8(4):555-63. doi: 10.1016/0739-7240(91)90025-f.