PMID- 17868217
OWN - NLM
STAT- MEDLINE
DCOM- 20071214
LR  - 20070917
IS  - 0105-1873 (Print)
IS  - 0105-1873 (Linking)
VI  - 57
IP  - 4
DP  - 2007 Oct
TI  - Comparative analysis of skin sensitization potency of acrylates (methyl acrylate, 
      ethyl acrylate, butyl acrylate, and ethylhexyl acrylate) using the local lymph 
      node assay.
PG  - 242-7
AB  - There are currently available no systematic experimental data on the skin 
      sensitizing properties of acrylates that are of relevance in occupational 
      settings. Limited information from previous guinea-pig tests or from the local 
      lymph node assay (LLNA) is available; however, these data are incomplete and 
      somewhat contradictory. For those reasons, we have examined in the LLNA 4 
      acrylates: butyl acrylate (BA), ethyl acrylate (EA), methyl acrylate (MA), and 
      ethylhexyl acrylate (EHA). The LLNA data indicated that all 4 compounds have some 
      potential to cause skin sensitization. In addition, the relative potencies of 
      these acrylates were measured by derivation from LLNA dose-response analyses of 
      EC3 values (the effective concentration of chemical required to induce a 
      threefold increase in proliferation of draining lymph node cells compared with 
      control values). On the basis of 1 scheme for the categorization of skin 
      sensitization potency, BA, EA, and MA were each classified as weak sensitizers. 
      Using the same scheme, EHA was considered a moderate sensitizer. However, it must 
      be emphasized that the EC3 value for this chemical of 9.7% is on the borderline 
      between moderate (<10%) and weak (>10%) categories. Thus, the judicious view is 
      that all 4 chemicals possess relatively weak skin sensitizing potential.
FAU - Dearman, Rebecca J
AU  - Dearman RJ
AD  - Immunology, Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, 
      Cheshire, SK1 4TJ, UK.
FAU - Betts, Catherine J
AU  - Betts CJ
FAU - Farr, Craig
AU  - Farr C
FAU - McLaughlin, James
AU  - McLaughlin J
FAU - Berdasco, Nancy
AU  - Berdasco N
FAU - Wiench, Karin
AU  - Wiench K
FAU - Kimber, Ian
AU  - Kimber I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Contact Dermatitis
JT  - Contact dermatitis
JID - 7604950
RN  - 0 (Acrylates)
RN  - 0 (Allergens)
SB  - IM
MH  - Acrylates/*toxicity
MH  - Allergens/*toxicity
MH  - Animals
MH  - Cell Proliferation
MH  - Dermatitis, Allergic Contact/*etiology
MH  - Disease Models, Animal
MH  - Female
MH  - *Local Lymph Node Assay
MH  - Lymph Nodes/pathology
MH  - Mice
MH  - Mice, Inbred CBA
MH  - Skin Tests
EDAT- 2007/09/18 09:00
MHDA- 2007/12/15 09:00
CRDT- 2007/09/18 09:00
PHST- 2007/09/18 09:00 [pubmed]
PHST- 2007/12/15 09:00 [medline]
PHST- 2007/09/18 09:00 [entrez]
AID - COD1215 [pii]
AID - 10.1111/j.1600-0536.2007.01215.x [doi]
PST - ppublish
SO  - Contact Dermatitis. 2007 Oct;57(4):242-7. doi: 10.1111/j.1600-0536.2007.01215.x.