PMID- 17870298
OWN - NLM
STAT- MEDLINE
DCOM- 20080205
LR  - 20181113
IS  - 1090-2139 (Electronic)
IS  - 0889-1591 (Print)
IS  - 0889-1591 (Linking)
VI  - 22
IP  - 2
DP  - 2008 Feb
TI  - SIV infection decreases sympathetic innervation of primate lymph nodes: the role 
      of neurotrophins.
PG  - 185-94
AB  - The sympathetic nervous system regulates immune responses in part through direct 
      innervation of lymphoid organs. Recent data indicate that viral infections can 
      alter the structure of lymph node innervation. To determine the molecular 
      mechanisms underlying sympathetic denervation during Simian Immunodeficiency 
      Virus (SIV) infection, we assessed the expression of neurotrophic factors and 
      neuromodulatory cytokines within lymph nodes from experimentally infected rhesus 
      macaques. Transcription of nerve growth factor (NGF), brain-derived neurotropic 
      factor (BDNF) and neurotrophin-4 (NT4) decreased significantly in vivo during 
      chronic SIV infection, whereas expression of the neuro-inhibitory cytokine 
      interferon-gamma (IFN gamma) was up-regulated. Acute SIV infection of macaque 
      leukocytes in vitro induced similar changes in the expression of neurotrophic and 
      neuro-inhibitory factors, indicative of an innate immune response. Statistical 
      mediation analyses of data from in vivo lymph node gene expression suggested that 
      coordinated changes in expression of multiple neuromodulatory factors may 
      contribute to SIV-induced depletion of catecholaminergic varicosities within 
      lymphoid tissue. Given previous evidence that lymph node catecholaminergic 
      varicosities can enhance SIV replication in vivo, these results are consistent 
      with the hypothesis that reduced expression of neurotrophic factors during 
      infection could constitute a neurobiological component of the innate immune 
      response to viral infection.
FAU - Sloan, Erica K
AU  - Sloan EK
AD  - University of California Los Angeles, Department of Medicine, Division of 
      Hematology-Oncology, UCLA School of Medicine, CA, USA. esloan@ucla.edu
FAU - Nguyen, Christina T
AU  - Nguyen CT
FAU - Cox, Benjamin F
AU  - Cox BF
FAU - Tarara, Ross P
AU  - Tarara RP
FAU - Capitanio, John P
AU  - Capitanio JP
FAU - Cole, Steve W
AU  - Cole SW
LA  - eng
GR  - CA116778/CA/NCI NIH HHS/United States
GR  - R01 CA116778/CA/NCI NIH HHS/United States
GR  - R01 AI052737/AI/NIAID NIH HHS/United States
GR  - MH049033/MH/NIMH NIH HHS/United States
GR  - AI/NS052737/AI/NIAID NIH HHS/United States
GR  - R01 CA116778-02/CA/NCI NIH HHS/United States
GR  - R01 MH049033/MH/NIMH NIH HHS/United States
GR  - R01 AI052737-04/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20070917
PL  - Netherlands
TA  - Brain Behav Immun
JT  - Brain, behavior, and immunity
JID - 8800478
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Leukemia Inhibitory Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neurotrophin 3)
RN  - 82115-62-6 (Interferon-gamma)
RN  - 9061-61-4 (Nerve Growth Factor)
RN  - P658DCA9XD (neurotrophin 4)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics
MH  - Gene Expression/immunology
MH  - Interferon-gamma/genetics
MH  - Leukemia Inhibitory Factor/genetics
MH  - Leukocytes/immunology/virology
MH  - Lymph Nodes/innervation/physiology/virology
MH  - Macaca mulatta
MH  - Nerve Growth Factor/genetics
MH  - Nerve Growth Factors/*genetics
MH  - Neurotrophin 3/genetics
MH  - Simian Acquired Immunodeficiency Syndrome/*immunology/physiopathology
MH  - Simian Immunodeficiency Virus/growth & development/*immunology
MH  - Sympathetic Nervous System/*immunology/*virology
MH  - Virus Replication
PMC - PMC2254209
MID - NIHMS38731
EDAT- 2007/09/18 09:00
MHDA- 2008/02/06 09:00
PMCR- 2009/02/01
CRDT- 2007/09/18 09:00
PHST- 2007/05/21 00:00 [received]
PHST- 2007/07/12 00:00 [revised]
PHST- 2007/07/13 00:00 [accepted]
PHST- 2007/09/18 09:00 [pubmed]
PHST- 2008/02/06 09:00 [medline]
PHST- 2007/09/18 09:00 [entrez]
PHST- 2009/02/01 00:00 [pmc-release]
AID - S0889-1591(07)00165-1 [pii]
AID - 10.1016/j.bbi.2007.07.008 [doi]
PST - ppublish
SO  - Brain Behav Immun. 2008 Feb;22(2):185-94. doi: 10.1016/j.bbi.2007.07.008. Epub 
      2007 Sep 17.