PMID- 17870532
OWN - NLM
STAT- MEDLINE
DCOM- 20080623
LR  - 20120604
IS  - 0960-894X (Print)
IS  - 0960-894X (Linking)
VI  - 17
IP  - 22
DP  - 2007 Nov 15
TI  - Novel heparin/heparan sulfate mimics as inhibitors of HGF/SF-induced MET 
      activation.
PG  - 6321-5
AB  - The synthesis of simple, non-sugar glycosaminoglycan (GAG) mimics has been 
      achieved and the analogues evaluated for their ability to inhibit the activation 
      of the MET receptor by hepatocyte growth factor/scatter factor (HGF/SF).
FAU - Raiber, Eun-Ang
AU  - Raiber EA
AD  - Centre for Molecular Drug Design, Cockcroft Building, University of Salford, 
      Salford, UK.
FAU - Wilkinson, James A
AU  - Wilkinson JA
FAU - Manetti, Fabrizio
AU  - Manetti F
FAU - Botta, Maurizio
AU  - Botta M
FAU - Deakin, Jon
AU  - Deakin J
FAU - Gallagher, John
AU  - Gallagher J
FAU - Lyon, Malcolm
AU  - Lyon M
FAU - Ducki, Sylvie W
AU  - Ducki SW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070904
PL  - England
TA  - Bioorg Med Chem Lett
JT  - Bioorganic & medicinal chemistry letters
JID - 9107377
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Receptors, Growth Factor)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - 9005-49-6 (Heparin)
RN  - 9050-30-0 (Heparitin Sulfate)
RN  - EC 2.7.10.1 (MET protein, human)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
SB  - IM
MH  - Animals
MH  - Cell Line
MH  - Cell Movement/drug effects
MH  - Computer Simulation
MH  - Dogs
MH  - Heparin/*pharmacology
MH  - Heparitin Sulfate/chemistry/*pharmacology
MH  - Hepatocyte Growth Factor/*metabolism
MH  - Models, Molecular
MH  - *Molecular Mimicry
MH  - Molecular Structure
MH  - Proto-Oncogene Proteins/*antagonists & inhibitors/*metabolism
MH  - Proto-Oncogene Proteins c-met
MH  - Receptors, Growth Factor/*antagonists & inhibitors/*metabolism
EDAT- 2007/09/18 09:00
MHDA- 2008/06/24 09:00
CRDT- 2007/09/18 09:00
PHST- 2007/05/14 00:00 [received]
PHST- 2007/08/30 00:00 [revised]
PHST- 2007/08/31 00:00 [accepted]
PHST- 2007/09/18 09:00 [pubmed]
PHST- 2008/06/24 09:00 [medline]
PHST- 2007/09/18 09:00 [entrez]
AID - S0960-894X(07)01031-1 [pii]
AID - 10.1016/j.bmcl.2007.08.074 [doi]
PST - ppublish
SO  - Bioorg Med Chem Lett. 2007 Nov 15;17(22):6321-5. doi: 10.1016/j.bmcl.2007.08.074. 
      Epub 2007 Sep 4.