PMID- 17872969
OWN - NLM
STAT- MEDLINE
DCOM- 20080104
LR  - 20190508
IS  - 1521-0111 (Electronic)
IS  - 0026-895X (Print)
IS  - 0026-895X (Linking)
VI  - 72
IP  - 6
DP  - 2007 Dec
TI  - Resveratrol (trans-3,5,4'-trihydroxystilbene) ameliorates experimental allergic 
      encephalomyelitis, primarily via induction of apoptosis in T cells involving 
      activation of aryl hydrocarbon receptor and estrogen receptor.
PG  - 1508-21
AB  - Resveratrol (trans-3,5,4'-trihydroxystilbene), a polyphenolic compound found in 
      plant products, including red grapes, exhibits anticancer, antioxidant, and 
      anti-inflammatory properties. Using an animal model of multiple sclerosis (MS), 
      we investigated the use of resveratrol for the treatment of autoimmune diseases. 
      We observed that resveratrol treatment decreased the clinical symptoms and 
      inflammatory responses in experimental allergic encephalomyelitis (EAE)-induced 
      mice. Furthermore, we observed significant apoptosis in inflammatory cells in 
      spinal cord of EAE-induced mice treated with resveratrol compared with the 
      control mice. Resveratrol administration also led to significant down-regulation 
      of certain cytokines and chemokines in EAE-induced mice including tumor necrosis 
      factor-alpha, interferon-gamma, interleukin (IL)-2, IL-9, IL-12, IL-17, 
      macrophage inflammatory protein-1alpha (MIP-1alpha), monocyte chemoattractant 
      protein-1 (MCP-1), regulated on activation normal T-cell expressed and secreted 
      (RANTES), and Eotaxin. In vitro studies on the mechanism of action revealed that 
      resveratrol triggered high levels of apoptosis in activated T cells and to a 
      lesser extent in unactivated T cells. Moreover, resveratrol-induced apoptosis was 
      mediated through activation of aryl hydrocarbon receptor (AhR) and estrogen 
      receptor (ER) and correlated with up-regulation of AhR, Fas, and FasL expression. 
      In addition, resveratrol-induced apoptosis in primary T cells correlated with 
      cleavage of caspase-8, caspase-9, caspase-3, poly(ADP-ribose) polymerase, and 
      release of cytochrome c. Data from the present study demonstrate, for the first 
      time, the ability of resveratrol to trigger apoptosis in activated T cells and 
      its potential use in the treatment of inflammatory and autoimmune diseases 
      including, MS.
FAU - Singh, Narendra P
AU  - Singh NP
AD  - Department of Pathology, Microbiology, and Immunology, University of South 
      Carolina School of Medicine, Columbia, SC 29208, USA.
FAU - Hegde, Venkatesh L
AU  - Hegde VL
FAU - Hofseth, Lorne J
AU  - Hofseth LJ
FAU - Nagarkatti, Mitzi
AU  - Nagarkatti M
FAU - Nagarkatti, Prakash
AU  - Nagarkatti P
LA  - eng
GR  - R01-HL058641/HL/NHLBI NIH HHS/United States
GR  - R01-AI053703/AI/NIAID NIH HHS/United States
GR  - R01 ES009098/ES/NIEHS NIH HHS/United States
GR  - P01-AT003961/AT/NCCIH NIH HHS/United States
GR  - P01 AT003961/AT/NCCIH NIH HHS/United States
GR  - R01 HL058641/HL/NHLBI NIH HHS/United States
GR  - F31 ES011562/ES/NIEHS NIH HHS/United States
GR  - R01 DA016545/DA/NIDA NIH HHS/United States
GR  - R21-DA014885/DA/NIDA NIH HHS/United States
GR  - R01-ES09098/ES/NIEHS NIH HHS/United States
GR  - R01 AI053703/AI/NIAID NIH HHS/United States
GR  - R01 AI058300/AI/NIAID NIH HHS/United States
GR  - F31-ES11562/ES/NIEHS NIH HHS/United States
GR  - R01-DA016545/DA/NIDA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20070914
PL  - United States
TA  - Mol Pharmacol
JT  - Molecular pharmacology
JID - 0035623
RN  - 0 (Receptors, Aryl Hydrocarbon)
RN  - 0 (Receptors, Estrogen)
RN  - 0 (Stilbenes)
RN  - Q369O8926L (Resveratrol)
SB  - IM
MH  - Animals
MH  - Apoptosis/drug effects/*physiology
MH  - Encephalomyelitis, Autoimmune, Experimental/*drug therapy/metabolism/*pathology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Receptors, Aryl Hydrocarbon/agonists/*metabolism
MH  - Receptors, Estrogen/agonists/*metabolism
MH  - Resveratrol
MH  - Stilbenes/pharmacology/*therapeutic use
MH  - T-Lymphocyte Subsets/drug effects/*metabolism
PMC - PMC4796949
MID - NIHMS760872
EDAT- 2007/09/18 09:00
MHDA- 2008/01/05 09:00
PMCR- 2016/03/18
CRDT- 2007/09/18 09:00
PHST- 2007/09/18 09:00 [pubmed]
PHST- 2008/01/05 09:00 [medline]
PHST- 2007/09/18 09:00 [entrez]
PHST- 2016/03/18 00:00 [pmc-release]
AID - mol.107.038984 [pii]
AID - 10.1124/mol.107.038984 [doi]
PST - ppublish
SO  - Mol Pharmacol. 2007 Dec;72(6):1508-21. doi: 10.1124/mol.107.038984. Epub 2007 Sep 
      14.