PMID- 17873759
OWN - NLM
STAT- MEDLINE
DCOM- 20080321
LR  - 20210108
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 86
IP  - 5
DP  - 2007 Sep
TI  - Clinical significance of thyroid disease in patients with inflammatory myopathy.
PG  - 293-298
LID - 10.1097/MD.0b013e318156f9c2 [doi]
AB  - We conducted the current study to determine the prevalence, incidence density, 
      and clinical significance of thyroid disease in a series of 109 patients 
      diagnosed with idiopathic inflammatory myopathy. We analyzed 109 patients 
      diagnosed with idiopathic inflammatory myopathy during a 20-year period 
      (1986-2006). Routine determination of thyroid profile, including hormone levels 
      and antithyroid antibodies (antithyroid peroxidase and antithyroglobulin antibody 
      systematically, and antithyroid-stimulating hormone receptor antibody when 
      appropriate) was carried out at onset and at least once again during the 
      follow-up period. Human leukocyte antigen (HLA) study was performed by polymerase 
      chain reaction sequence-specific oligonucleotide typing. Six patients (5.5%) 
      developed thyroid disease (hypo- or hyperthyroidism), with an incidence density 
      of 8.7 new cases per 1000 person-years; 4 of the 6 cases were of autoimmune 
      origin (3.6%). Thyroid dysfunction, whether autoimmune or not, was clearly 
      related with onset or relapse of disease activity. Neoplastic disease was 
      detected in 3 of 4 (75%) patients with autoimmune thyroid disease, a 
      significantly higher frequency than was observed in the remaining patients in the 
      series (12 of 103, 11.7%; p < 0.05; RR: 22.8; 95% confidence interval, 
      2.2-236.6). HLA DRB1*04 was found in 4 of the 6 patients with thyroid disease and 
      inflammatory myopathy. Thyroid disorders are clinically relevant in patients with 
      inflammatory myopathies. An association was observed between autoimmune thyroid 
      disease and cancer. Thyroid assessment is strongly recommended in patients with 
      idiopathic inflammatory myopathy and clinical relapse.
FAU - Selva-O'Callaghan, Albert
AU  - Selva-O'Callaghan A
AD  - From Internal Medicine Department (ASO'C, ARB, ETA, MVT) and Preventive Medicine 
      and Epidemiology Department (XMG), Vall d'Hebron General Hospital, Universitat 
      Autonoma Barcelona; and Lirad (EP), Banc Sang I Teixits, Barcelona, Spain.
FAU - Redondo-Benito, Ada
AU  - Redondo-Benito A
FAU - Trallero-Araguas, Ernesto
AU  - Trallero-Araguas E
FAU - Martinez-Gomez, Xavier
AU  - Martinez-Gomez X
FAU - Palou, Eduard
AU  - Palou E
FAU - Vilardell-Tarres, Miquel
AU  - Vilardell-Tarres M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Biomarkers)
RN  - 0 (Genetic Markers)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Follow-Up Studies
MH  - Genetic Markers/genetics
MH  - HLA-A Antigens/genetics
MH  - HLA-B Antigens/genetics
MH  - Histocompatibility Testing
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Myositis/*complications
MH  - Polymerase Chain Reaction
MH  - Prevalence
MH  - Research Design
MH  - Spain/epidemiology
MH  - Thyroid Diseases/epidemiology/*etiology/pathology
EDAT- 2007/09/18 09:00
MHDA- 2008/03/22 09:00
CRDT- 2007/09/18 09:00
PHST- 2007/09/18 09:00 [pubmed]
PHST- 2008/03/22 09:00 [medline]
PHST- 2007/09/18 09:00 [entrez]
AID - 00005792-200709000-00005 [pii]
AID - 10.1097/MD.0b013e318156f9c2 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2007 Sep;86(5):293-298. doi: 10.1097/MD.0b013e318156f9c2.