PMID- 17873824
OWN - NLM
STAT- MEDLINE
DCOM- 20080103
LR  - 20161018
IS  - 0894-9115 (Print)
IS  - 0894-9115 (Linking)
VI  - 86
IP  - 11
DP  - 2007 Nov
TI  - Muscle strength in relation to disease severity in patients with congestive heart 
      failure.
PG  - 893-900
AB  - OBJECTIVE: Indices of exercise capacity such as peak oxygen uptake (VO2peak) and 
      muscle strength are important in association with reduced mortality. The present 
      study compared differences in VO2peak and muscle strength indices (grip strength 
      and knee extensor and flexor muscle strength) with disease severity and 
      investigated the relation of these variables in congestive heart failure (CHF) 
      patients. DESIGN: The study comprised 102 patients with stable CHF (93 men, age 
      61.4 +/- 10.2 yrs) with left ventricular ejection fraction (LVEF) <40% by 
      echocardiography. We used New York Heart Association (NYHA) functional class to 
      index disease severity. VO2peak, grip strength, knee extensor, and flexor muscle 
      strength were determined. Patients were divided into three groups by NYHA class: 
      class I (n = 39), class II (n = 49), and class III (n = 14). RESULTS: Age, sex, 
      and LVEF did not differ according to NYHA class. VO2peak and all muscle strength 
      indices decreased with increases in NYHA class (P < 0.05). VO2peak correlated 
      positively with all muscle strengths (P < 0.05). Stepwise linear regression 
      analysis revealed that grip and knee extensor strength were important in 
      predicting VO2peak. CONCLUSIONS: Exercise capacity and disease severity in CHF 
      patients may be influenced not only by lower-limb but also upper-limb muscle 
      strength.
FAU - Izawa, Kazuhiro P
AU  - Izawa KP
AD  - Department of Rehabilitation Medicine, St. Marianna University School of Medicine 
      Hospital, Kanagawa, Japan.
FAU - Watanabe, Satoshi
AU  - Watanabe S
FAU - Yokoyama, Hitoshi
AU  - Yokoyama H
FAU - Hiraki, Koji
AU  - Hiraki K
FAU - Morio, Yuji
AU  - Morio Y
FAU - Oka, Koichiro
AU  - Oka K
FAU - Osada, Naohiko
AU  - Osada N
FAU - Omiya, Kazuto
AU  - Omiya K
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Phys Med Rehabil
JT  - American journal of physical medicine & rehabilitation
JID - 8803677
SB  - IM
MH  - Exercise
MH  - Female
MH  - Heart Failure/*classification/drug therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Muscle Strength
MH  - *Oxygen Consumption
MH  - Severity of Illness Index
MH  - Ventricular Function, Left
EDAT- 2007/09/18 09:00
MHDA- 2008/01/04 09:00
CRDT- 2007/09/18 09:00
PHST- 2007/09/18 09:00 [pubmed]
PHST- 2008/01/04 09:00 [medline]
PHST- 2007/09/18 09:00 [entrez]
AID - 10.1097/PHM.0b013e318154b592 [doi]
PST - ppublish
SO  - Am J Phys Med Rehabil. 2007 Nov;86(11):893-900. doi: 
      10.1097/PHM.0b013e318154b592.