PMID- 17874836
OWN - NLM
STAT- MEDLINE
DCOM- 20071105
LR  - 20190902
IS  - 0301-4800 (Print)
IS  - 0301-4800 (Linking)
VI  - 53
IP  - 3
DP  - 2007 Jun
TI  - Oral administration of the extract from Hatakeshimeji (Lyophyllum decastes sing.) 
      mushroom inhibits the development of atopic dermatitis-like skin lesions in 
      NC/Nga mice.
PG  - 293-6
AB  - We examined whether the extract from Hatakeshimeji (Lyophyllum decastes, LD) 
      mushrooms suppresses the development of atopic dermatitis (AD)-like skin lesions 
      induced by repeated application of picryl chloride (PiCl) in NC/Nga mice. Oral 
      administration of LD extract to NC/Nga mice inhibited the development of AD-like 
      skin lesions based on lower total skin severity scores and serum immunoglobulin E 
      (IgE) levels. Splenic lymphocytes were stimulated with the T cell mitogen 
      concanavalin A, and secretion of a Th1 cytokine (IFN-gamma) and a Th2 cytokine 
      (IL-4) was determined by ELISA. IFN-gamma production was not inhibited by 
      treatment with LD extract. On the other hand, IL-4 production was significantly 
      decreased by treatment with LD extract. These results suggest that LD extract 
      exerts anti-allergic actions by suppressing the serum IgE and Th2-type immune 
      responses.
FAU - Ukawa, Yuuichi
AU  - Ukawa Y
AD  - Oji Forest & Products Co., Ltd., 1-1-1 Shinkiba, Koutou-ku, Tokyo 136-0082, 
      Japan. ukawa@vc.tnc.ne.jp
FAU - Izumi, Yoshiya
AU  - Izumi Y
FAU - Ohbuchi, Takayuki
AU  - Ohbuchi T
FAU - Takahashi, Tetsunari
AU  - Takahashi T
FAU - Ikemizu, Shoichi
AU  - Ikemizu S
FAU - Kojima, Yasushi
AU  - Kojima Y
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - J Nutr Sci Vitaminol (Tokyo)
JT  - Journal of nutritional science and vitaminology
JID - 0402640
RN  - 0 (Plant Extracts)
RN  - 11028-71-0 (Concanavalin A)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 820484N8I3 (Histamine)
RN  - 82115-62-6 (Interferon-gamma)
RN  - Z4ZG7O5SZ9 (Picryl Chloride)
SB  - IM
MH  - Administration, Oral
MH  - *Agaricales/chemistry
MH  - Animals
MH  - Concanavalin A
MH  - Dermatitis, Atopic/chemically induced/*prevention & control
MH  - Disease Models, Animal
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Histamine/blood/immunology
MH  - Immunoglobulin E/blood/drug effects
MH  - Interferon-gamma/drug effects/immunology
MH  - Interleukin-4/immunology
MH  - Lymphocytes/drug effects/immunology
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Phytotherapy/methods
MH  - Picryl Chloride
MH  - Plant Extracts/administration & dosage
MH  - Severity of Illness Index
MH  - Skin/*drug effects/immunology
MH  - Spleen/drug effects/immunology
MH  - Time Factors
EDAT- 2007/09/19 09:00
MHDA- 2007/11/06 09:00
CRDT- 2007/09/19 09:00
PHST- 2007/09/19 09:00 [pubmed]
PHST- 2007/11/06 09:00 [medline]
PHST- 2007/09/19 09:00 [entrez]
AID - 10.3177/jnsv.53.293 [doi]
PST - ppublish
SO  - J Nutr Sci Vitaminol (Tokyo). 2007 Jun;53(3):293-6. doi: 10.3177/jnsv.53.293.