PMID- 17875344
OWN - NLM
STAT- MEDLINE
DCOM- 20080122
LR  - 20181113
IS  - 0196-9781 (Print)
IS  - 1873-5169 (Electronic)
IS  - 0196-9781 (Linking)
VI  - 28
IP  - 10
DP  - 2007 Oct
TI  - Chronic caloric restriction induces forestomach hypertrophy with enhanced ghrelin 
      levels during aging.
PG  - 1931-6
AB  - Caloric restriction (CR) is the only preventive intervention that has robust 
      pro-longevity effects in experimental models. Various circulating hormones that 
      regulate the state of negative energy balance may drive the multi-system 
      beneficial effects of the CR phenomenon. Ghrelin, one such stomach-derived 
      circulating peptide hormone stimulates food intake, promotes GH release and 
      inhibits pro-inflammatory cytokines. We have recently demonstrated that ghrelin 
      also reverses age-related thymic involution. Here, we report that chronic CR in 
      aging mice results in reduction in body weight, and spleen size but remarkably, 
      leads to a significant increase in the size and weight of stomach. The increased 
      size of stomach was largely due to increased size of fundus (forestomach) and 
      also smaller but statistically significant enlargement of antrum. The analysis of 
      serial stomach sections revealed that chronic CR leads to a striking hypertrophy 
      of lamina propria, stratum basale, stratum corneum and the stratified squamous 
      epithelium of forestomach of the aged animals. We also report for the first time 
      that chronic CR during aging significantly increases circulating ghrelin levels 
      as well as total ghrelin production in the stomach and reverses age-related loss 
      of ghrelin receptor expression in pituitary. Our data suggests that long-term 
      CR-induced increased ghrelin production from hypertrophic stomach in mice may be 
      an adaptive survival strategy in response to sustained negative energy balance 
      that triggers heightened state of food seeking. Taken together, these data 
      provide new insights into the underlying mechanism behind the salutary effects of 
      chronic caloric restriction during aging process.
FAU - Yang, Hyunwon
AU  - Yang H
AD  - Laboratory of Neuroendocrine-Immunology, Pennington Biomedical Research Center, 
      Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA.
FAU - Youm, Yun-Hee
AU  - Youm YH
FAU - Nakata, Chiaki
AU  - Nakata C
FAU - Dixit, Vishwa Deep
AU  - Dixit VD
LA  - eng
GR  - P20 RR021945/RR/NCRR NIH HHS/United States
GR  - P30 DK072476/DK/NIDDK NIH HHS/United States
GR  - 1 P20 RR02/1945/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20070819
PL  - United States
TA  - Peptides
JT  - Peptides
JID - 8008690
RN  - 0 (Ghrelin)
SB  - IM
MH  - Aging/*metabolism/pathology
MH  - Animals
MH  - *Caloric Restriction
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Ghrelin/biosynthesis/*metabolism
MH  - Hypertrophy
MH  - Immunohistochemistry
MH  - Mice
MH  - Polymerase Chain Reaction
MH  - Stomach/*pathology
PMC - PMC5682623
MID - NIHMS917892
EDAT- 2007/09/19 09:00
MHDA- 2008/01/23 09:00
PMCR- 2017/11/13
CRDT- 2007/09/19 09:00
PHST- 2007/06/28 00:00 [received]
PHST- 2007/07/26 00:00 [revised]
PHST- 2007/07/26 00:00 [accepted]
PHST- 2007/09/19 09:00 [pubmed]
PHST- 2008/01/23 09:00 [medline]
PHST- 2007/09/19 09:00 [entrez]
PHST- 2017/11/13 00:00 [pmc-release]
AID - S0196-9781(07)00275-6 [pii]
AID - 10.1016/j.peptides.2007.07.030 [doi]
PST - ppublish
SO  - Peptides. 2007 Oct;28(10):1931-6. doi: 10.1016/j.peptides.2007.07.030. Epub 2007 
      Aug 19.