PMID- 17875675
OWN - NLM
STAT- MEDLINE
DCOM- 20071107
LR  - 20181113
IS  - 0022-1007 (Print)
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Linking)
VI  - 204
IP  - 10
DP  - 2007 Oct 1
TI  - The transcription factor XBP-1 is essential for the development and survival of 
      dendritic cells.
PG  - 2267-75
AB  - Dendritic cells (DCs) play a critical role in the initiation, maintenance, and 
      resolution of an immune response. DC survival is tightly controlled by 
      extracellular stimuli such as cytokines and Toll-like receptor (TLR) signaling, 
      but the intracellular events that translate such extracellular stimuli into life 
      or death for the DC remain poorly understood. The endoplasmic reticulum (ER) 
      stress, or unfolded protein response (UPR), is a signaling pathway that is 
      activated when unfolded proteins accumulate in the ER. The most conserved arm of 
      the UPR involves IRE1alpha, an ER transmembrane kinase and endoribonuclease that 
      activates the transcription factor XBP-1 to maintain ER homeostasis and prevent 
      activation of cell death pathways caused by sustained ER stress. We report that 
      XBP-1 is essential for DC development and survival. Lymphoid chimeras lacking 
      XBP-1 possessed decreased numbers of both conventional and plasmacytoid DCs with 
      reduced survival both at baseline and in response to TLR signaling. 
      Overexpression of XBP-1 in hematopoietic progenitors rescued and enhanced DC 
      development. Remarkably, in contrast to other cell types we have examined, the 
      XBP-1 pathway was constitutively activated in immature DCs.
FAU - Iwakoshi, Neal N
AU  - Iwakoshi NN
AD  - Department of Immunology and Infectious Diseases, Harvard School of Public 
      Health, Boston, MA 02115, USA.
FAU - Pypaert, Marc
AU  - Pypaert M
FAU - Glimcher, Laurie H
AU  - Glimcher LH
LA  - eng
GR  - P01 AI056296/AI/NIAID NIH HHS/United States
GR  - R01 AI032412/AI/NIAID NIH HHS/United States
GR  - AI32412/AI/NIAID NIH HHS/United States
GR  - AI56296/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20070917
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Regulatory Factor X Transcription Factors)
RN  - 0 (Transcription Factors)
RN  - 0 (X-Box Binding Protein 1)
RN  - 0 (Xbp1 protein, mouse)
SB  - IM
MH  - Animals
MH  - Cell Differentiation/*immunology
MH  - Cell Survival
MH  - Cells, Cultured
MH  - DNA-Binding Proteins/deficiency/genetics/*immunology/*metabolism
MH  - Dendritic Cells/*cytology/*immunology/metabolism
MH  - Endoplasmic Reticulum/immunology/metabolism
MH  - Lymphocytes/immunology/metabolism
MH  - Mice
MH  - Mice, Knockout
MH  - Microscopy, Electron
MH  - Regulatory Factor X Transcription Factors
MH  - Sensitivity and Specificity
MH  - Transcription Factors/deficiency/genetics/*immunology/*metabolism
MH  - X-Box Binding Protein 1
PMC - PMC2118458
EDAT- 2007/09/19 09:00
MHDA- 2007/11/08 09:00
PMCR- 2008/04/01
CRDT- 2007/09/19 09:00
PHST- 2007/09/19 09:00 [pubmed]
PHST- 2007/11/08 09:00 [medline]
PHST- 2007/09/19 09:00 [entrez]
PHST- 2008/04/01 00:00 [pmc-release]
AID - jem.20070525 [pii]
AID - 20070525 [pii]
AID - 10.1084/jem.20070525 [doi]
PST - ppublish
SO  - J Exp Med. 2007 Oct 1;204(10):2267-75. doi: 10.1084/jem.20070525. Epub 2007 Sep 
      17.