PMID- 17876613
OWN - NLM
STAT- MEDLINE
DCOM- 20080616
LR  - 20181113
IS  - 1432-6981 (Print)
IS  - 1432-6981 (Linking)
VI  - 12
IP  - 1
DP  - 2008 Mar
TI  - Gingival levels of monocyte chemoattractant protein-1 (MCP-1) in diabetes 
      mellitus and periodontitis: an experimental study in rats.
PG  - 83-9
AB  - The objectives of this study were to investigate and compare the monocyte 
      chemoattractant protein-1 (MCP-1) levels of gingival tissues in diabetes mellitus 
      (DM) and periodontitis and to reveal the effects of MCP-1 on periodontal 
      inflammation and destruction in these diseases. DM was created in 15 rats (group 
      1) by streptozotocin injection, and periodontitis was obtained by ligature 
      induction in 15 rats (group 2). Fifteen systemically and periodontally healthy 
      rats were used as control (group 3). Gingival MCP-1 levels were measured by 
      enzyme-linked immunosorbent assay (ELISA). Periodontal inflammation was 
      quantified by the inflammatory cell infiltration in the gingival samples, whereas 
      periodontal destruction was assessed by the alveolar bone loss in the 
      experimental regions. MCP-1 concentrations were higher in groups 1 and 2 than in 
      group 3 (p < 0.001). Increased gingival inflammatory cell infiltration and 
      alveolar bone loss were observed in groups 1 and 2 compared to group 3 (p < 
      0.001). There were positive correlations among the MCP-1 level, gingival 
      inflammatory cell infiltration, and alveolar bone loss in groups 1 and 2 (p < 
      0.001). Our results suggest that (1) DM may lead to enhanced MCP-1 production in 
      periodontal tissues likewise for periodontitis and (2) there may be a positive 
      correlation between the MCP-1 concentration and diseased nature of periodontium 
      in both diseases.
FAU - Sakallioglu, Elif Eser
AU  - Sakallioglu EE
AD  - Department of Periodontology, Ondokuz Mayis University Dental Faculty, 55139, 
      Samsun, Turkey. eseracarel2000@yahoo.com
FAU - Ayas, Bulent
AU  - Ayas B
FAU - Lutfioglu, Muge
AU  - Lutfioglu M
FAU - Keles, Gonca Cayir
AU  - Keles GC
FAU - Acikgoz, Gokhan
AU  - Acikgoz G
FAU - Firatli, Erhan
AU  - Firatli E
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20070918
PL  - Germany
TA  - Clin Oral Investig
JT  - Clinical oral investigations
JID - 9707115
RN  - 0 (Autoantigens)
RN  - 0 (Ccl2 protein, rat)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cytokines)
RN  - 5W494URQ81 (Streptozocin)
MH  - Alveolar Bone Loss/classification/immunology
MH  - Animals
MH  - Autoantigens/*analysis
MH  - Chemokine CCL2/*analysis
MH  - Connective Tissue/pathology
MH  - Cytokines/*analysis
MH  - Diabetes Mellitus, Experimental/*immunology
MH  - Epithelium/pathology
MH  - Gingiva/*immunology/pathology
MH  - Gingivitis/immunology/pathology
MH  - Lymphocytes/pathology
MH  - Male
MH  - Monocytes/pathology
MH  - Periodontitis/*immunology/pathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Streptozocin
EDAT- 2007/09/19 09:00
MHDA- 2008/06/17 09:00
CRDT- 2007/09/19 09:00
PHST- 2007/03/19 00:00 [received]
PHST- 2007/08/16 00:00 [accepted]
PHST- 2007/09/19 09:00 [pubmed]
PHST- 2008/06/17 09:00 [medline]
PHST- 2007/09/19 09:00 [entrez]
AID - 10.1007/s00784-007-0148-6 [doi]
PST - ppublish
SO  - Clin Oral Investig. 2008 Mar;12(1):83-9. doi: 10.1007/s00784-007-0148-6. Epub 
      2007 Sep 18.