PMID- 17876981
OWN - NLM
STAT- MEDLINE
DCOM- 20071031
LR  - 20181211
IS  - 0047-1852 (Print)
IS  - 0047-1852 (Linking)
VI  - 65
IP  - 9
DP  - 2007 Sep
TI  - [Molecular biology of depressive disorders].
PG  - 1599-606
AB  - Heritability of major depression from twin studies is estimated as -40% that is 
      relatively small as compared with -80% for schizophrenia and -90% for bipolar 
      affective disorder. It suggests that genetic as well as environmental factors 
      contribute to the aetiology of major depression. Approximately 800 association 
      studies on candidate genes of depression have been published, and among them, 
      several genes were confirmed as risk for vulnerability to major depression by 
      meta-analyses. Recent investigations on pathophysiology of depression have 
      focused on hippocampus as a modulator of Hypothalamus-Pituitary-Adrenal (HPA) 
      glands axis. Molecular biological studies on the interaction between stress, 
      hippocampus and HPA axis reveal glucocorticoid and brain-derived neurotrophic 
      factor(BDNF) are key molecules developing and recovering from depressive 
      disorder.
FAU - Itokawa, Masanari
AU  - Itokawa M
AD  - Schizophrenia Research Project, Tokyo Institute of Psychiatry.
FAU - Yoshikawa, Takeo
AU  - Yoshikawa T
LA  - jpn
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Nihon Rinsho
JT  - Nihon rinsho. Japanese journal of clinical medicine
JID - 0420546
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (CD56 Antigen)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Glucocorticoids)
RN  - 0 (NCAM1 protein, human)
RN  - 0 (Neural Cell Adhesion Molecules)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Regulatory Factor X Transcription Factors)
RN  - 0 (Transcription Factors)
RN  - EC 1.6.99.3 (NADH Dehydrogenase)
RN  - EC 3.1.3.2 (Phosphoric Monoester Hydrolases)
RN  - EC 3.1.3.25 (myo-inositol-1 (or 4)-monophosphatase)
RN  - EC 7.1.1.2 (NDUFV2 protein, human)
SB  - IM
MH  - Brain-Derived Neurotrophic Factor
MH  - CD56 Antigen
MH  - DNA-Binding Proteins/genetics
MH  - Depressive Disorder/*genetics
MH  - Glucocorticoids
MH  - Hippocampus
MH  - Humans
MH  - Hypothalamo-Hypophyseal System
MH  - Meta-Analysis as Topic
MH  - NADH Dehydrogenase/genetics
MH  - Neural Cell Adhesion Molecules/genetics
MH  - Nuclear Proteins/genetics
MH  - Phosphoric Monoester Hydrolases/genetics
MH  - Pituitary-Adrenal System
MH  - Regulatory Factor X Transcription Factors
MH  - Transcription Factors
RF  - 20
EDAT- 2007/09/20 09:00
MHDA- 2007/11/01 09:00
CRDT- 2007/09/20 09:00
PHST- 2007/09/20 09:00 [pubmed]
PHST- 2007/11/01 09:00 [medline]
PHST- 2007/09/20 09:00 [entrez]
PST - ppublish
SO  - Nihon Rinsho. 2007 Sep;65(9):1599-606.