PMID- 17877443
OWN - NLM
STAT- MEDLINE
DCOM- 20071022
LR  - 20191110
IS  - 1744-764X (Electronic)
IS  - 1474-0338 (Linking)
VI  - 6
IP  - 5
DP  - 2007 Sep
TI  - A review of the safety of 50% nitrous oxide/oxygen in conscious sedation.
PG  - 559-71
AB  - Few studies into conscious sedation with 50% nitrous oxide/oxygen premix (50% 
      N2O/O2) have been conducted in accordance with Good Clinical Practice in Clinical 
      Trials. Of the 140 articles retained in this review, the incidence of adverse 
      events (AEs) varied in the range of 0-68% according to the indications. When 
      other drugs and/or local anaesthesia were used concomitantly, the relative risk 
      for nausea and vomiting increased whereas it decreased for vertigo or 
      hallucinations. Only one study examined potential causal relationship between 
      serious AEs and the 50% N2O/O2 gas itself, giving a risk for a serious AE 
      directly due to the gas of 3/10,000 administrations. No analysis of the effect of 
      the method of administration was possible, nor could conclusions be drawn 
      relating to the risk of occupational exposure.
FAU - Collado, Valerie
AU  - Collado V
AD  - Univ Clermont1, EA 3847, Faculte d'Odontologie, 11 bvd Charles de Gaulle, F-63000 
      Clermont-Ferrand, France. valerie.collado@u-clermont1.fr
FAU - Nicolas, Emmanuel
AU  - Nicolas E
FAU - Faulks, Denise
AU  - Faulks D
FAU - Hennequin, Martine
AU  - Hennequin M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Expert Opin Drug Saf
JT  - Expert opinion on drug safety
JID - 101163027
RN  - 0 (Anesthetics, Inhalation)
RN  - K50XQU1029 (Nitrous Oxide)
SB  - IM
MH  - Anesthetics, Inhalation/adverse effects/chemistry
MH  - Animals
MH  - Conscious Sedation/*adverse effects/methods
MH  - Humans
MH  - Nitrous Oxide/*adverse effects/chemistry
MH  - Risk Factors
RF  - 87
EDAT- 2007/09/20 09:00
MHDA- 2007/10/24 09:00
CRDT- 2007/09/20 09:00
PHST- 2007/09/20 09:00 [pubmed]
PHST- 2007/10/24 09:00 [medline]
PHST- 2007/09/20 09:00 [entrez]
AID - 10.1517/14740338.6.5.559 [doi]
PST - ppublish
SO  - Expert Opin Drug Saf. 2007 Sep;6(5):559-71. doi: 10.1517/14740338.6.5.559.