PMID- 17877512
OWN - NLM
STAT- MEDLINE
DCOM- 20080103
LR  - 20070919
IS  - 0269-2813 (Print)
IS  - 0269-2813 (Linking)
VI  - 26
IP  - 7
DP  - 2007 Oct 1
TI  - Long-term use of proton pump inhibitors does not affect the frequency, growth, or 
      histologic characteristics of colon adenomas.
PG  - 1051-61
AB  - BACKGROUND: The clinical significance of the trophic effects of long-term proton 
      pump inhibitors (PPI)-related hypergastrinemia on colon polyps remains unknown. 
      AIM: To study the frequency, growth, and histology of colon polyps in patients on 
      chronic PPI therapy (cases), compared to those not receiving acid suppression 
      (controls). METHODS: Medical records of 2868 consecutive patients who underwent 
      two or more colonoscopies, performed 3 or more months apart were reviewed. Cases 
      (116) that used PPIs between the two colonoscopies were then compared to controls 
      (194). RESULTS: Demographics and risk factors for colon cancer were comparable 
      between the two groups. At baseline the mean frequency and size of adenomatous 
      polyps were similar in cases and controls (P > 0.05) and at follow-up, these were 
      0.89 and 1.18 (P > 0.05; 95% CI of -0.08 to 0.66) and 4.09 mm and 4.00 mm (P > 
      0.05; 95% CI -2.29 to 2.11), respectively with no significant change. However, 
      control group had a higher mean frequency and size of hyperplastic polyps at 
      baseline as well as at follow-up colonoscopy (P < 0.05). CONCLUSIONS: The 
      long-term use of PPI does not influence the frequency, growth, or histology of 
      adenomatous polyps, but is associated with a reduction in both baseline and 
      interval development of hyperplastic polyps.
FAU - Singh, M
AU  - Singh M
AD  - Gastroenterology Section, Veterans Affairs Health Care System, Palo Alto, CA, 
      USA.
FAU - Dhindsa, G
AU  - Dhindsa G
FAU - Friedland, S
AU  - Friedland S
FAU - Triadafilopoulos, G
AU  - Triadafilopoulos G
LA  - eng
GR  - DK063624/DK/NIDDK NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - Aliment Pharmacol Ther
JT  - Alimentary pharmacology & therapeutics
JID - 8707234
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Adenomatous Polyps/*drug therapy/metabolism
MH  - Colonic Polyps/*drug therapy/metabolism
MH  - Colonoscopy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Proton Pump Inhibitors/metabolism/*therapeutic use
MH  - Retrospective Studies
MH  - Treatment Outcome
EDAT- 2007/09/20 09:00
MHDA- 2008/01/04 09:00
CRDT- 2007/09/20 09:00
PHST- 2007/09/20 09:00 [pubmed]
PHST- 2008/01/04 09:00 [medline]
PHST- 2007/09/20 09:00 [entrez]
AID - APT3450 [pii]
AID - 10.1111/j.1365-2036.2007.03450.x [doi]
PST - ppublish
SO  - Aliment Pharmacol Ther. 2007 Oct 1;26(7):1051-61. doi: 
      10.1111/j.1365-2036.2007.03450.x.