PMID- 17879008
OWN - NLM
STAT- MEDLINE
DCOM- 20071130
LR  - 20070919
IS  - 0723-5003 (Print)
IS  - 0723-5003 (Linking)
VI  - 102
IP  - 9
DP  - 2007 Sep 15
TI  - [Disproportionate shortening of left ventricular diastolic duration in patients 
      with dilated cardiomyopathy].
PG  - 707-13
AB  - BACKGROUND AND PURPOSE: Cardiac performance can be characterized in terms of the 
      relative duration of systole and diastole. In pediatric patients with dilated 
      cardiomyopathy (DCM), a disproportionate shortening of left ventricular diastole 
      was observed. The present study was intended to reproduce these findings in an 
      adult patient group and to evaluate exercise-related changes of both time 
      intervals. PATIENTS AND METHODS: Exercise radionuclide angiography was used in 61 
      patients with DCM NYHA (New York Heart Association) stage II-III. The phases of 
      the cardiac cycle were derived from a radionuclide time-activity curve with high 
      temporal resolution. The control group consisted of 26 patients referred for 
      ventricular function assessment with radionuclide angiography before cardiotoxic 
      cancer treatment. RESULTS: When the duration of systole was expressed as the 
      product of systolic time and heart rate, DCM patients exhibited a significant 
      increase in left ventricular systolic time at rest (23.9 vs. 21.5 s/min; p = 
      0.006) and during peak exercise (29.2 vs. 26.7 s/min; p = 0.01). The prolongation 
      of left ventricular systole at peak exercise was evident, although the peak heart 
      rate was significantly lower in the patient group than in the control group (118 
      vs. 127/min; p = 0.04). In DCM patients the diastolic time loss per beat was 
      further quantified using a regression equation obtained from the healthy control 
      group. A significant shortening of left ventricular diastolic time was confirmed 
      during peak exercise. Furthermore, a progressive loss in diastolic time per beat 
      from rest to peak exercise was noted. CONCLUSION: Cardiac cycle abnormalities of 
      patients with DCM are characterized by a prolongation of left ventricular systole 
      and an abnormal shortening of left ventricular diastole. The systolic-diastolic 
      mismatch is accentuated during exercise and has the potential to impair the 
      cardiac reserve in these patients by restricting ventricular filling and 
      perfusion.
FAU - Plehn, Gunnar
AU  - Plehn G
AD  - Medizinische Klinik II (Schwerpunkte Kardiologie und Angiologie), Marienhospital 
      Herne, Ruhr-Universitat, Bochum. gunnar.plehn@ruhr-uni-bochum.de
FAU - Vormbrock, Julia
AU  - Vormbrock J
FAU - Zuhlke, Christian
AU  - Zuhlke C
FAU - Christ, Martin
AU  - Christ M
FAU - Perings, Christian
AU  - Perings C
FAU - Perings, Stefan
AU  - Perings S
FAU - Trappe, Hans-Joachim
AU  - Trappe HJ
FAU - Meissner, Axel
AU  - Meissner A
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Abnorme Verkurzung der linksventrikularen Diastolendauer unter korperlicher 
      Belastung bei Patienten mit dilatativer Kardiomyopathie.
PL  - Germany
TA  - Med Klin (Munich)
JT  - Medizinische Klinik (Munich, Germany : 1983)
JID - 8303501
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cardiomyopathy, Dilated/diagnosis/*physiopathology
MH  - Diastole/*physiology
MH  - Electrocardiography
MH  - *Exercise Test
MH  - Female
MH  - Gated Blood-Pool Imaging
MH  - Heart Failure/diagnosis/physiopathology
MH  - Heart Rate/physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Reference Values
MH  - Systole/physiology
MH  - Ventricular Dysfunction, Left/diagnosis/*physiopathology
EDAT- 2007/09/20 09:00
MHDA- 2007/12/06 09:00
CRDT- 2007/09/20 09:00
PHST- 2007/03/28 00:00 [received]
PHST- 2007/07/17 00:00 [accepted]
PHST- 2007/09/20 09:00 [pubmed]
PHST- 2007/12/06 09:00 [medline]
PHST- 2007/09/20 09:00 [entrez]
AID - 10.1007/s00063-007-1089-1 [doi]
PST - ppublish
SO  - Med Klin (Munich). 2007 Sep 15;102(9):707-13. doi: 10.1007/s00063-007-1089-1.