PMID- 17879214
OWN - NLM
STAT- MEDLINE
DCOM- 20080122
LR  - 20101118
IS  - 1121-8428 (Print)
IS  - 1121-8428 (Linking)
VI  - 20
IP  - 4
DP  - 2007 Jul-Aug
TI  - Cystatin C as marker of residual renal function in patients on peritoneal 
      dialysis: relation with parameters of peritoneal function.
PG  - 468-73
AB  - INTRODUCTION: Cystatin C (CysC) is a nonglycosylated protein of low molecular 
      weight not influenced by age, sex or inflammation. The aim of this paper is to 
      ascertain the usefulness of serum CysC level determination in peritoneal dialysis 
      (PD) patients. MATERIAL AND METHODS: CysC serum levels were determined in 80 PD 
      patients. The mean age of patients was 53.7 +/- 15 years, with 15.3 +/- 25.8 
      months on PD. Thirty-three percent were on continuous ambulatory peritoneal 
      dialysis (CAPD) and 66.3% on automated peritoneal dialysis (APD). Fourteen 
      patients (17%) had no residual renal function (RRF). RESULTS: Mean CysC levels 
      were 5.8 +/- 1.4 mg/L, without differences between men (5.5 +/- 1.4 mg/L) and 
      women (5.6 +/- 1.5 mg/L, NS). There was no correlation between CysC levels and 
      age, weight, height or time on PD. Anuric patients had CysC levels significantly 
      higher than non-anuric (6.7 +/- 1.4 vs. 5.3 +/- 1.3 mg/L, p<0.001). CysC levels 
      showed an inverse correlation with RRF (r=-0.60, p<0.001) and residual urine 
      volume (r=-0.58, p<0.001). CONCLUSIONS: In conclusion, serum CysC levels had the 
      same statistical significance as plasma creatinine levels, and they are not 
      influenced by peritoneal transport in PD patients. Consequently, both parameters 
      are valid RRF markers.
FAU - Ros, Silvia
AU  - Ros S
AD  - Nephrology and Biochemistry Unit, University Hospital La Paz, Madrid, Spain. 
      silviarr@universia.es
FAU - Bajo, Auxiliadora
AU  - Bajo A
FAU - del Peso, Gloria
AU  - del Peso G
FAU - Garcia de Miguel, Auxiliadora
AU  - Garcia de Miguel A
FAU - Santacruz, Soledad
AU  - Santacruz S
FAU - Fernandez, Ernesto
AU  - Fernandez E
FAU - de Garcia, Raquel
AU  - de Garcia R
FAU - Selgas, Rafael
AU  - Selgas R
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - J Nephrol
JT  - Journal of nephrology
JID - 9012268
RN  - 0 (CST3 protein, human)
RN  - 0 (Cystatin C)
RN  - 0 (Cystatins)
SB  - IM
MH  - Aged
MH  - Cystatin C
MH  - Cystatins/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Peritoneal Dialysis
MH  - Renal Insufficiency/*diagnosis/*physiopathology
EDAT- 2007/09/20 09:00
MHDA- 2008/01/23 09:00
CRDT- 2007/09/20 09:00
PHST- 2007/09/20 09:00 [pubmed]
PHST- 2008/01/23 09:00 [medline]
PHST- 2007/09/20 09:00 [entrez]
PST - ppublish
SO  - J Nephrol. 2007 Jul-Aug;20(4):468-73.