PMID- 17882234
OWN - NLM
STAT- MEDLINE
DCOM- 20080214
LR  - 20220409
IS  - 0893-133X (Print)
IS  - 0893-133X (Linking)
VI  - 33
IP  - 1
DP  - 2008 Jan
TI  - Interaction between BDNF and serotonin: role in mood disorders.
PG  - 73-83
AB  - Brain-derived neurotrophic factor (BDNF) and serotonin (5-hydroxytryptamine, 
      5-HT) are two seemingly distinct signaling systems that play regulatory roles in 
      many neuronal functions including survival, neurogenesis, and synaptic 
      plasticity. A common feature of the two systems is their ability to regulate the 
      development and plasticity of neural circuits involved in mood disorders such as 
      depression and anxiety. BDNF promotes the survival and differentiation of 5-HT 
      neurons. Conversely, administration of antidepressant selective serotonin 
      reuptake inhibitors (SSRIs) enhances BDNF gene expression. There is also evidence 
      for synergism between the two systems in affective behaviors and genetic epitasis 
      between BDNF and the serotonin transporter genes.
FAU - Martinowich, Keri
AU  - Martinowich K
AD  - Mood and Anxiety Disorders Program (MAP), NIMH, National Institutes of Health, 
      Bethesda, MD 20892-3714, USA.
FAU - Lu, Bai
AU  - Lu B
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20070919
PL  - England
TA  - Neuropsychopharmacology
JT  - Neuropsychopharmacology : official publication of the American College of 
      Neuropsychopharmacology
JID - 8904907
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 333DO1RDJY (Serotonin)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Gene Expression Regulation/physiology
MH  - Humans
MH  - Mood Disorders/genetics/*metabolism/pathology
MH  - Neurons/metabolism/pathology
MH  - Serotonin/genetics/*metabolism
RF  - 130
EDAT- 2007/09/21 09:00
MHDA- 2008/02/15 09:00
CRDT- 2007/09/21 09:00
PHST- 2007/09/21 09:00 [pubmed]
PHST- 2008/02/15 09:00 [medline]
PHST- 2007/09/21 09:00 [entrez]
AID - 1301571 [pii]
AID - 10.1038/sj.npp.1301571 [doi]
PST - ppublish
SO  - Neuropsychopharmacology. 2008 Jan;33(1):73-83. doi: 10.1038/sj.npp.1301571. Epub 
      2007 Sep 19.