PMID- 17882260
OWN - NLM
STAT- MEDLINE
DCOM- 20071211
LR  - 20240109
IS  - 1460-2075 (Electronic)
IS  - 0261-4189 (Print)
IS  - 0261-4189 (Linking)
VI  - 26
IP  - 20
DP  - 2007 Oct 17
TI  - Coa1 links the Mss51 post-translational function to Cox1 cofactor insertion in 
      cytochrome c oxidase assembly.
PG  - 4335-46
AB  - The assembly of cytochrome c oxidase (CcO) in yeast mitochondria is shown to be 
      dependent on a new assembly factor designated Coa1 that associates with the 
      mitochondrial inner membrane. Translation of the mitochondrial-encoded subunits 
      of CcO occurs normally in coa1Delta cells, but these subunits fail to accumulate. 
      The respiratory defect in coa1Delta cells is suppressed by high-copy MSS51, MDJ1 
      and COX10. Mss51 functions in Cox1 translation and elongation, whereas Cox10 
      participates in the biosynthesis of heme a, a key cofactor of CcO. Respiration in 
      coa1Delta and shy1Delta cells is enhanced when Mss51 and Cox10 are coexpressed. 
      Shy1 has been implicated in formation of the heme a3-Cu(B) site in Cox1. The 
      interaction between Coa1 and Cox1, and the physical and genetic interactions 
      between Coa1 and Mss51, Shy1 and Cox14 suggest that Coa1 coordinates the 
      transition of newly synthesized Cox1 from the Mss51:Cox14 complex to the heme a 
      cofactor insertion involving Shy1. coa1Delta cells also display a mitochondrial 
      copper defect suggesting that Coa1 may have a direct link to copper metallation 
      of CcO.
FAU - Pierrel, Fabien
AU  - Pierrel F
AD  - Department of Medicine, University of Utah Health Sciences Center, University of 
      Utah, Salt Lake City, UT 84132, USA.
FAU - Bestwick, Megan L
AU  - Bestwick ML
FAU - Cobine, Paul A
AU  - Cobine PA
FAU - Khalimonchuk, Oleh
AU  - Khalimonchuk O
FAU - Cricco, Julia A
AU  - Cricco JA
FAU - Winge, Dennis R
AU  - Winge DR
LA  - eng
GR  - R01 ES003817/ES/NIEHS NIH HHS/United States
GR  - R37 ES003817/ES/NIEHS NIH HHS/United States
GR  - DK P30 072437/DK/NIDDK NIH HHS/United States
GR  - ES 03817/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20070920
PL  - England
TA  - EMBO J
JT  - The EMBO journal
JID - 8208664
RN  - 0 (COX14 protein, S cerevisiae)
RN  - 0 (Fungal Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Mitochondrial Proteins)
RN  - 0 (Mss51 protein, S cerevisiae)
RN  - 0 (Nuclear Proteins)
RN  - 0 (SHY1 protein, S cerevisiae)
RN  - 0 (Saccharomyces cerevisiae Proteins)
RN  - 0 (Transcription Factors)
RN  - 42VZT0U6YR (Heme)
RN  - 789U1901C5 (Copper)
RN  - EC 1.9.3.1 (Electron Transport Complex IV)
SB  - IM
MH  - Copper/chemistry
MH  - Electron Transport Complex IV/chemistry/*physiology
MH  - Fungal Proteins/*physiology
MH  - *Gene Expression Regulation, Fungal
MH  - Heme/chemistry
MH  - Membrane Proteins/physiology
MH  - Mitochondria/metabolism
MH  - Mitochondrial Proteins
MH  - Models, Biological
MH  - Nuclear Proteins/physiology
MH  - Oxygen Consumption
MH  - Protein Binding
MH  - Protein Biosynthesis
MH  - *Protein Processing, Post-Translational
MH  - Saccharomyces cerevisiae Proteins/*physiology
MH  - Transcription Factors/*physiology
PMC - PMC2034670
EDAT- 2007/09/21 09:00
MHDA- 2007/12/12 09:00
PMCR- 2008/10/17
CRDT- 2007/09/21 09:00
PHST- 2007/04/10 00:00 [received]
PHST- 2007/08/09 00:00 [accepted]
PHST- 2007/09/21 09:00 [pubmed]
PHST- 2007/12/12 09:00 [medline]
PHST- 2007/09/21 09:00 [entrez]
PHST- 2008/10/17 00:00 [pmc-release]
AID - 7601861 [pii]
AID - 10.1038/sj.emboj.7601861 [doi]
PST - ppublish
SO  - EMBO J. 2007 Oct 17;26(20):4335-46. doi: 10.1038/sj.emboj.7601861. Epub 2007 Sep 
      20.