PMID- 17883412
OWN - NLM
STAT- MEDLINE
DCOM- 20080129
LR  - 20101118
IS  - 0953-816X (Print)
IS  - 0953-816X (Linking)
VI  - 26
IP  - 7
DP  - 2007 Oct
TI  - BDNF/ TrkB interaction regulates migration of SVZ precursor cells via PI3-K and 
      MAP-K signalling pathways.
PG  - 1780-90
AB  - Neuroblasts born in the subventricular zone (SVZ) migrate along the rostral 
      migratory stream, reaching the olfactory bulb (OB) where they differentiate into 
      local interneurons. Several extracellular factors have been suggested to control 
      specific steps of this process. The brain-derived neurotrophic factor (BDNF) has 
      been demonstrated to promote morphological differentiation and survival of OB 
      interneurons. Here we show that BDNF and its receptor TrkB are expressed in vivo 
      throughout the migratory pathway, implying that BDNF might also mediate migratory 
      signals. By using in vitro models we demonstrate that BDNF promotes migration of 
      SVZ neuroblasts, acting both as inducer and attractant through TrkB activation. 
      We show that BDNF induces cAMP response element-binding protein (CREB) activation 
      in migrating neuroblasts via phosphatidylinositol 3-kinase (PI3-K) and 
      mitogen-activated protein kinase (MAP-K) signalling. Pharmacological blockade of 
      these pathways on SVZ explants significantly reduces CREB activation and impairs 
      neuronal migration. This study identifies a function of BDNF in the SVZ system, 
      which involves multiple protein kinase pathways leading to neuroblast migration.
FAU - Chiaramello, S
AU  - Chiaramello S
AD  - Department of Animal and Human Biology, University of Turin, 10123 Turin, Italy.
FAU - Dalmasso, G
AU  - Dalmasso G
FAU - Bezin, L
AU  - Bezin L
FAU - Marcel, D
AU  - Marcel D
FAU - Jourdan, F
AU  - Jourdan F
FAU - Peretto, P
AU  - Peretto P
FAU - Fasolo, A
AU  - Fasolo A
FAU - De Marchis, S
AU  - De Marchis S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070920
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (RNA, Messenger)
RN  - EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism/pharmacology
MH  - Cell Movement/*physiology
MH  - Cerebral Ventricles/*cytology/growth & development
MH  - Chemotaxis/drug effects/physiology
MH  - Dose-Response Relationship, Drug
MH  - Drug Interactions
MH  - Enzyme Inhibitors/pharmacology
MH  - Enzyme-Linked Immunosorbent Assay/methods
MH  - Mice
MH  - Mitogen-Activated Protein Kinases/*physiology
MH  - Neurons/*physiology
MH  - Phosphatidylinositol 3-Kinases/*physiology
MH  - RNA, Messenger/biosynthesis
MH  - Receptor, trkB/genetics/*metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction/methods
MH  - Signal Transduction/*physiology
MH  - Stem Cells/*physiology
EDAT- 2007/09/22 09:00
MHDA- 2008/01/30 09:00
CRDT- 2007/09/22 09:00
PHST- 2007/09/22 09:00 [pubmed]
PHST- 2008/01/30 09:00 [medline]
PHST- 2007/09/22 09:00 [entrez]
AID - EJN5818 [pii]
AID - 10.1111/j.1460-9568.2007.05818.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 2007 Oct;26(7):1780-90. doi: 10.1111/j.1460-9568.2007.05818.x. 
      Epub 2007 Sep 20.