PMID- 17884190
OWN - NLM
STAT- MEDLINE
DCOM- 20080314
LR  - 20191210
IS  - 0166-4328 (Print)
IS  - 0166-4328 (Linking)
VI  - 186
IP  - 2
DP  - 2008 Jan 25
TI  - Dietary zinc supplementation during pregnancy prevents spatial and object 
      recognition memory impairments caused by early prenatal ethanol exposure.
PG  - 230-8
AB  - Alcohol-induced zinc (Zn) deficiency is one of the mechanisms proposed as a cause 
      of ethanol teratogenicity. Subcutaneous Zn treatment with ethanol in early 
      pregnancy has been shown to prevent birth abnormalities and memory impairments in 
      mice. This study examined whether dietary Zn supplementation throughout pregnancy 
      can prevent cognitive impairments caused by early ethanol exposure. Pregnant 
      C57BL/6J mice were fed either a control (35 microg Zn/g) or Zn-supplemented (200 
      microg Zn/g) diet throughout pregnancy. On gestational day (GD) 8, mice received 
      two intraperitoneal injections (4h apart) of either saline or 25% ethanol (0.015 
      mL/g). All offspring were screened for physical and behavioural defects (e.g. 
      growth, visual, exploratory, anxiety, motor deficits). Twenty-four 
      phenotypically-normal offspring were randomly selected from each of the four 
      treatment groups (saline +/- Zn-supplementation, ethanol +/- Zn-supplementation) 
      and tested at 60 d of age using a cross-maze escape task for spatial learning and 
      memory impairments, and an object recognition task. While no differences were 
      observed between treatments for spatial learning, offspring exposed to ethanol 
      demonstrated spatial memory impairments at both 12 and 28 d after learning an 
      escape task, with less correct trials and increased escape latency scores 
      compared with saline-treated mice. Furthermore, these mice also exhibited 
      impairments in object recognition memory. In comparison, ethanol-exposed 
      offspring from dams fed a Zn-supplemented diet throughout pregnancy did not 
      display spatial memory or object recognition deficits, performing at the same 
      level as saline-treated offspring. Therefore, dietary Zn-supplementation during 
      pregnancy prevents spatial and object recognition memory impairments caused by 
      ethanol exposure during early pregnancy.
FAU - Summers, Brooke L
AU  - Summers BL
AD  - Hanson Institute, Institute of Medical and Veterinary Science, Adelaide, SA 5000, 
      Australia.
FAU - Henry, Catherine M A
AU  - Henry CM
FAU - Rofe, Allan M
AU  - Rofe AM
FAU - Coyle, Peter
AU  - Coyle P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070819
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Alcohols)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Age Factors
MH  - *Alcohols
MH  - Analysis of Variance
MH  - Animals
MH  - Animals, Newborn
MH  - Avoidance Learning/drug effects
MH  - Body Size/drug effects
MH  - Female
MH  - Male
MH  - Maze Learning/drug effects
MH  - Memory Disorders/*etiology/*prevention & control
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*physiopathology
MH  - Reaction Time/drug effects
MH  - Recognition, Psychology/*drug effects
MH  - Time Factors
MH  - Zinc/*administration & dosage
EDAT- 2007/09/22 09:00
MHDA- 2008/03/15 09:00
CRDT- 2007/09/22 09:00
PHST- 2007/03/13 00:00 [received]
PHST- 2007/08/10 00:00 [revised]
PHST- 2007/08/13 00:00 [accepted]
PHST- 2007/09/22 09:00 [pubmed]
PHST- 2008/03/15 09:00 [medline]
PHST- 2007/09/22 09:00 [entrez]
AID - S0166-4328(07)00422-6 [pii]
AID - 10.1016/j.bbr.2007.08.011 [doi]
PST - ppublish
SO  - Behav Brain Res. 2008 Jan 25;186(2):230-8. doi: 10.1016/j.bbr.2007.08.011. Epub 
      2007 Aug 19.