PMID- 17886237
OWN - NLM
STAT- MEDLINE
DCOM- 20080107
LR  - 20071116
IS  - 1860-7314 (Electronic)
IS  - 1860-6768 (Linking)
VI  - 2
IP  - 11
DP  - 2007 Nov
TI  - Fabrication of lab-on chip platforms by hot embossing and photo patterning.
PG  - 1381-8
AB  - In this paper, we review the approaches developed in our laboratory to fabricate 
      polymer-based microfluidic devices to suit a range of applications in bio- or 
      chemical analysis. Thermoplastic materials such as polycarbonate (PC) and 
      poly(methyl methacrylate) (PMMA) are used to fabricate microfluidic devices via 
      hot embossing. To emboss microchannels, we use hard stamps fabricated in silicon 
      or soft stamps molded on poly(dimethylsiloxane) (PDMS). Hard stamps are 
      fabricated on silicon wafers through photolithography and deep reactive ion 
      etching (DRIE). Soft stamps are fabricated by casting PDMS prepolymer on silicon 
      molds. To enclose the fluidic channels, direct fusion bonding was found to 
      produce the highest bond strength with minimal structural deformation. One-step 
      photolithographic methods have also been explored to produce via photochemical 
      patterning microfluidic structures in photocurable materials. We use the 
      photocurable capabilities of a PDMS copolymer, which incorporates a methacrylate 
      crosslinker. Microfluidic channels are produced via one step-photopatterning 
      processes by crosslinking the prepolymer mixture through a photomask. The smaller 
      feature size attainable was 100 microm. Structures with higher spatial resolution 
      are fabricated through a photoimprinting process whereby a mold is pressed 
      against the precured mixture during UV crosslinking exposure. The application of 
      the fabricated fluidic devices in electrophoretic ion analysis is also presented.
FAU - Maurya, Devendra K
AU  - Maurya DK
AD  - Institute of Materials Research and Engineering, 3 Research Link, Singapore.
FAU - Ng, Wee Yang
AU  - Ng WY
FAU - Mahabadi, Kambiz Ansari
AU  - Mahabadi KA
FAU - Liang, Yen Nan
AU  - Liang YN
FAU - Rodriguez, Isabel
AU  - Rodriguez I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Biotechnol J
JT  - Biotechnology journal
JID - 101265833
RN  - 0 (Polymers)
RN  - 0 (Silicones)
RN  - 9011-14-7 (Polymethyl Methacrylate)
SB  - IM
MH  - Electrophoresis, Microchip/instrumentation/methods
MH  - Microfluidics/instrumentation/*methods
MH  - Nanotechnology/instrumentation/methods
MH  - Polymers/*chemistry
MH  - Polymethyl Methacrylate/chemistry
MH  - Silicones/chemistry
EDAT- 2007/09/22 09:00
MHDA- 2008/01/08 09:00
CRDT- 2007/09/22 09:00
PHST- 2007/09/22 09:00 [pubmed]
PHST- 2008/01/08 09:00 [medline]
PHST- 2007/09/22 09:00 [entrez]
AID - 10.1002/biot.200700107 [doi]
PST - ppublish
SO  - Biotechnol J. 2007 Nov;2(11):1381-8. doi: 10.1002/biot.200700107.