PMID- 17886678
OWN - NLM
STAT- MEDLINE
DCOM- 20110719
LR  - 20070924
IS  - 1673-0860 (Print)
IS  - 1673-0860 (Linking)
VI  - 42
IP  - 7
DP  - 2007 Jul
TI  - [Expression of monocyte chemotactic protein 1 and vascular endothelial growth 
      factor in nasal polyps].
PG  - 508-10
AB  - OBJECTIVE: To evaluate the relationship between the expression of monocyte 
      chemotactic protein 1 (MCP-1) and vascular endothelial growth factor (VEGF) in 
      nasal polyp (NP) tissues and the role of MCP-1 in the formation of nasal polyps. 
      METHODS: Forty nasal polyp tissues obtained from NP patients were used to detect 
      the expression of MCP-1 and VEGF at the levels of protein and mRNA by 
      immunohistochemical and in situ hybridization assay. Twenty-five inferior 
      turbinate (IT) samples obtained from chronic rhinitis patients were used as 
      control. RESULTS: The expression of MCP-1 and VEGF was higher in NP tissue than 
      in IT at protein and mRNA levels (P <0.01). The expression of these two cytokines 
      was positively correlated(r = 0.871, P <0.05). CONCLUSIONS: MCP-1 and VEGF were 
      involved in the formation of nasal polyps.
FAU - She, Cui-ping
AU  - She CP
AD  - Department of Otorhinolaryngology Head and Neck Surgery, China-Japan Union 
      Hospital, Jilin University, Changchun 130033, China.
FAU - Guan, Gui-mei
AU  - Guan GM
FAU - Zhu, Dong-dong
AU  - Zhu DD
FAU - Dong, Zhen
AU  - Dong Z
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of 
      otorhinolaryngology head and neck surgery
JID - 101247574
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chemokine CCL2/*metabolism
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nasal Mucosa/metabolism
MH  - Nasal Polyps/*metabolism/pathology
MH  - Vascular Endothelial Growth Factor A/*metabolism
EDAT- 2007/09/25 09:00
MHDA- 2011/07/20 06:00
CRDT- 2007/09/25 09:00
PHST- 2007/09/25 09:00 [pubmed]
PHST- 2011/07/20 06:00 [medline]
PHST- 2007/09/25 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2007 Jul;42(7):508-10.