PMID- 17888527
OWN - NLM
STAT- MEDLINE
DCOM- 20080311
LR  - 20131121
IS  - 0166-4328 (Print)
IS  - 0166-4328 (Linking)
VI  - 187
IP  - 1
DP  - 2008 Feb 11
TI  - GnRH mediates estrous behavior induced by ring A reduced progestins and 
      vaginocervical stimulation.
PG  - 1-8
AB  - The present study was designed to assess the participation of 
      gonadotropin-releasing hormone (GnRH) in the display of estrous behavior induced 
      by application of vaginal-cervical stimulation (VCS) and by the 
      intracerebroventricular (icv) administration of progesterone and its ring 
      A-reduced metabolites to ovariectomized (ovx), estradiol benzoate (E2B) primed 
      rats. Icv injection of Antide, a GnRH-1 receptor antagonist, significantly 
      depressed lordosis behavior in ovx, E2B-primed rats treated with icv GnRH. 
      Application of VCS to ovx, E2B-primed rats facilitated both lordosis and 
      proceptivity. These behavioral responses were significantly depressed by the icv 
      administration of Antide. Similarly, icv Antide blocked the stimulatory effect on 
      both lordosis and proceptive behaviors elicited by progesterone and its ring 
      A-reduced metabolites: 5alpha-pregnandione (5alpha-DHP), 
      5alpha-pregnan-3alpha-ol-20-one (5alpha,3alpha-Pgl) and 
      5beta-pregnan-3beta-hydroxy-20-one (5beta,3beta-Pgl) in ovx, E2B-primed rats. By 
      contrast, icv injection of Antide failed to interfere with the facilitatory 
      effect of the synthetic progestin megestrol acetate on lordosis and proceptive 
      behaviors. This progestin is not reduced in ring A. The results suggest that GnRH 
      release is an important process in the chain of events leading to the display of 
      estrous behavior in response to progesterone, its ring A-reduced metabolites, and 
      VCS in female rats.
FAU - Gomora-Arrati, Porfirio
AU  - Gomora-Arrati P
AD  - Centro de Investigacion en Reproduccion Animal, CINVESTAV Universidad Autonoma de 
      Tlaxcala. Apdo. 62, Tlaxcala, c.p. 90000, Mexico.
FAU - Beyer, Carlos
AU  - Beyer C
FAU - Lima-Hernandez, Francisco Javier
AU  - Lima-Hernandez FJ
FAU - Gracia, Maria Elena
AU  - Gracia ME
FAU - Etgen, Anne M
AU  - Etgen AM
FAU - Gonzalez-Flores, Oscar
AU  - Gonzalez-Flores O
LA  - eng
GR  - R37 MH41414/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20070822
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Hormone Antagonists)
RN  - 0 (Oligopeptides)
RN  - 0 (Progestins)
RN  - 33515-09-2 (Gonadotropin-Releasing Hormone)
RN  - 4TI98Z838E (Estradiol)
RN  - 94055UOQ3Y (iturelix)
RN  - TJ2M0FR8ES (Megestrol Acetate)
SB  - IM
MH  - Animals
MH  - Cervix Uteri/*physiology
MH  - Estradiol/pharmacology
MH  - Estrous Cycle/*drug effects
MH  - Female
MH  - Gonadotropin-Releasing Hormone/*antagonists & inhibitors/metabolism/*pharmacology
MH  - Hormone Antagonists/*pharmacology
MH  - Injections, Intraventricular
MH  - Megestrol Acetate/antagonists & inhibitors/pharmacology
MH  - Oligopeptides/*pharmacology
MH  - Ovariectomy
MH  - Physical Stimulation
MH  - Posture
MH  - Progestins/chemistry/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sexual Behavior, Animal/*drug effects
MH  - Vagina/*physiology
EDAT- 2007/09/25 09:00
MHDA- 2008/03/12 09:00
CRDT- 2007/09/25 09:00
PHST- 2007/03/01 00:00 [received]
PHST- 2007/06/09 00:00 [revised]
PHST- 2007/08/20 00:00 [accepted]
PHST- 2007/09/25 09:00 [pubmed]
PHST- 2008/03/12 09:00 [medline]
PHST- 2007/09/25 09:00 [entrez]
AID - S0166-4328(07)00431-7 [pii]
AID - 10.1016/j.bbr.2007.08.017 [doi]
PST - ppublish
SO  - Behav Brain Res. 2008 Feb 11;187(1):1-8. doi: 10.1016/j.bbr.2007.08.017. Epub 
      2007 Aug 22.