PMID- 17889114
OWN - NLM
STAT- MEDLINE
DCOM- 20071113
LR  - 20220408
IS  - 0041-1345 (Print)
IS  - 0041-1345 (Linking)
VI  - 39
IP  - 7
DP  - 2007 Sep
TI  - Venous graft thrombosis in patients on peritoneal dialysis before 
      transplantation.
PG  - 2128-30
AB  - BACKGROUND: It has been described that patients on peritoneal dialysis (PD) 
      suffer from thrombotic events (vascular access, deep venous thrombosis, and graft 
      thrombosis) more frequently after transplantation than other recipients. We 
      analyzed the incidence of allograft thrombosis among patients transplanted in a 
      6-year period (January 1, 2000, to December 31, 2005) to identify etiological 
      factors, such as inherited thrombophilia. MATERIALS AND METHODS: We performed 197 
      renal transplants in 189 patients, including 115 who had been on hemodialysis 
      (HD), 44 on PD, and 30 preemptive. We recorded immunological and demographic 
      data, studied graft and patient survivals, and evaluated the hypercoagulable 
      state of those who experienced graft thrombosis. RESULTS: The mean age of the 
      patients at transplantation was 49 years. There were no demographic or 
      immunological differences between the three groups of patients, except for the 
      number of previous blood transfusions and panel reactive antibodies (PRA) levels. 
      Forty-seven grafts were lost in the first year; 14 suffered venous thrombosis, 
      and there were 10 acute rejection epidoses (ARE), 7 death-censored graft 
      failures, 3 chronic allograft nephropathies (CAN), 6 primary nonfunctions, 5 
      removed due to infection, 1 primary disease relapse, and 1 hemolytic-uremic 
      syndrome. Of the 14 cases of thrombosis in 12 patients, 10 had been on PD and 4 
      on HD immediately before transplant. One-year graft and patient survivals were 
      similar: 74% HD, 68% PD, 86% preemptive, and 93% HD, 95% PD, and 96% preemptive, 
      respectively. The hypercoagulable state showed inherited thrombophilia patterns 
      in some cases, but most of them were normal. CONCLUSION: Renal graft thrombosis 
      was responsible for graft lost in PD patients within the first year, while in the 
      HD group it was ARE and in the preemptive cohort, death with a functioning graft. 
      The hypercoagulable state pretransplant should be more accurately studied to 
      identify thrombotic factors other than those which are inherited.
FAU - Palomar, R
AU  - Palomar R
AD  - Nephrology Department, Marques de Valdecilla Hospital, Santander, Spain. 
      nefpfm@humv.es
FAU - Morales, P
AU  - Morales P
FAU - Rodrigo, E
AU  - Rodrigo E
FAU - Castaneda, O
AU  - Castaneda O
FAU - Fernandez-Fresnedo, G
AU  - Fernandez-Fresnedo G
FAU - Gomez-Alamillo, C
AU  - Gomez-Alamillo C
FAU - Arias, M
AU  - Arias M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - Cause of Death
MH  - Humans
MH  - Kidney Failure, Chronic/surgery/therapy
MH  - Kidney Transplantation/mortality/*pathology/physiology
MH  - Middle Aged
MH  - Peritoneal Dialysis/*adverse effects
MH  - Renal Veins/surgery
MH  - Retrospective Studies
MH  - Survival Analysis
MH  - Thrombophilia/complications
MH  - Venous Thrombosis/epidemiology/*pathology
EDAT- 2007/09/25 09:00
MHDA- 2007/11/14 09:00
CRDT- 2007/09/25 09:00
PHST- 2007/09/25 09:00 [pubmed]
PHST- 2007/11/14 09:00 [medline]
PHST- 2007/09/25 09:00 [entrez]
AID - S0041-1345(07)00738-5 [pii]
AID - 10.1016/j.transproceed.2007.06.022 [doi]
PST - ppublish
SO  - Transplant Proc. 2007 Sep;39(7):2128-30. doi: 10.1016/j.transproceed.2007.06.022.