PMID- 17890005
OWN - NLM
STAT- MEDLINE
DCOM- 20080117
LR  - 20151119
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 426
IP  - 2
DP  - 2007 Oct 16
TI  - The paraventricular nucleus of hypothalamus mediates the pressor response to 
      noradrenergic stimulation of the medial prefrontal cortex in unanesthetized rats.
PG  - 101-5
AB  - The medial prefrontal cortex (MPFC) is a structure that is also involved in 
      cardiovascular modulation. The injection of norepinephrine (NE) into the 
      prelimbic (PL) area of the MPFC of unanesthetized rats evokes a pressor response 
      which is mediated by acute vasopressin release. Vasopressin is synthesized by 
      magnocellular cells of the paraventricular (PVN) and supraoptic nucleus (SON) of 
      the hypothalamus. In the present study, we endeavored to determine which 
      vasopressin-synthesizing hypothalamic nucleus is involved in the pressor pathway 
      activated after NE injection into the PL area of the MPFC. We report here that 
      lidocaine microinjection into the SON did not change the pressor response evoked 
      by NE injection into the PL. However, the response to NE was blocked by prior 
      injection of lidocaine or CoCl(2) into the PVN, indicating that this area is 
      responsible for the mediation of this pressor response. A neuroanatomic 
      experiment in which the neuronal tracer biotinylated dextran amine (BDA) was 
      microinjected into the MPFC showed a lack of axons or neuronal cell bodies in the 
      PVN, indicating that there are no direct connections between the PL area of the 
      MPFC and the PVN. The results suggest that the PVN is involved in the mediation 
      of the pressor response to NE in the PL area and that this pathway must relay in 
      other brain structures before reaching the PVN.
FAU - Fernandes, Karen Barros Parron
AU  - Fernandes KB
AD  - School of Dentistry, North Parana University, UNOPAR, Brazil.
FAU - Tavares, Rodrigo Fiacadori
AU  - Tavares RF
FAU - Pelosi, Gislaine Garcia
AU  - Pelosi GG
FAU - Correa, Fernando Morgan Aguiar
AU  - Correa FM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070906
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Anesthetics, Local)
RN  - 0 (Antimutagenic Agents)
RN  - 0 (Sympathomimetics)
RN  - 11000-17-2 (Vasopressins)
RN  - 3G0H8C9362 (Cobalt)
RN  - 98PI200987 (Lidocaine)
RN  - EVS87XF13W (cobaltous chloride)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Anesthetics, Local/pharmacology
MH  - Animals
MH  - Antimutagenic Agents/pharmacology
MH  - Blood Pressure/*drug effects/physiology
MH  - Cobalt/pharmacology
MH  - Drug Interactions
MH  - Lidocaine/pharmacology
MH  - Male
MH  - Neural Pathways/drug effects/physiology
MH  - Norepinephrine/*pharmacology
MH  - Paraventricular Hypothalamic Nucleus/drug effects/metabolism/*physiology
MH  - Prefrontal Cortex/*drug effects/physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Sympathomimetics/*pharmacology
MH  - Vasopressins/metabolism
MH  - *Wakefulness
EDAT- 2007/09/25 09:00
MHDA- 2008/01/18 09:00
CRDT- 2007/09/25 09:00
PHST- 2007/05/22 00:00 [received]
PHST- 2007/08/31 00:00 [revised]
PHST- 2007/08/31 00:00 [accepted]
PHST- 2007/09/25 09:00 [pubmed]
PHST- 2008/01/18 09:00 [medline]
PHST- 2007/09/25 09:00 [entrez]
AID - S0304-3940(07)00952-4 [pii]
AID - 10.1016/j.neulet.2007.08.063 [doi]
PST - ppublish
SO  - Neurosci Lett. 2007 Oct 16;426(2):101-5. doi: 10.1016/j.neulet.2007.08.063. Epub 
      2007 Sep 6.