PMID- 17890489
OWN - NLM
STAT- MEDLINE
DCOM- 20080110
LR  - 20131121
IS  - 1930-7381 (Print)
IS  - 1930-7381 (Linking)
VI  - 15
IP  - 9
DP  - 2007 Sep
TI  - Relationship of plasma adiponectin with sex hormone and insulin-like growth 
      factor levels.
PG  - 2217-24
AB  - OBJECTIVE: Recent studies have suggested that a relationship between adiponectin 
      and sex hormone, prolactin, and insulin-like growth factor levels could be 
      important for breast cancer risk and insulin sensitivity. Therefore, we assessed 
      the relationship of adiponectin with plasma concentrations of estrone; estradiol; 
      estrone sulfate; testosterone; androstenedione; dehydroepiandrosterone (DHEA); 
      dehydroepiandrosterone sulfate (DHEAS); sex hormone binding globulin (SHBG); 
      prolactin; insulin-like growth factor (IGF-1); its binding protein, IGF binding 
      protein 3 (IGFBP-3); c-peptide; and IGF binding protein 1 (IGFBP-1) among 360 
      postmenopausal women not taking postmenopausal hormones from the Nurses' Health 
      Study. RESEARCH METHODS AND PROCEDURES: Multivariate models were adjusted for 
      physical activity, alcohol consumption, age at blood draw, age at first 
      birth/parity, fasting status, and time of day of blood draw; a separate model was 
      additionally adjusted for BMI at blood draw. RESULTS: Estrogens were inversely 
      associated with adiponectin levels; however, except for free estradiol, these 
      associations were substantially attenuated after adjustment for BMI. Free 
      estradiol levels were 27% lower among women in the top vs. bottom quartile of 
      adiponectin levels. No consistent associations were observed for the androgens, 
      prolactin, IGF-1, and IGFBP-3. However, SHBG, c-peptide, and IGFBP-1 were 
      strongly and independently associated with adiponectin levels (r = 0.29, -0.30, 
      0.24, respectively). CONCLUSION: With the exceptions of SHBG, c-peptide, and 
      IGFBP-1, the studied analytes were modestly associated with adiponectin and the 
      associations were, in large part, mediated by body fat.
FAU - Tworoger, Shelley S
AU  - Tworoger SS
AD  - Channing Laboratory, 181 Longwood Ave., 3rd Floor, Boston, MA 02115, USA. 
      nhsst@channing.harvard.edu
FAU - Mantzoros, Christos
AU  - Mantzoros C
FAU - Hankinson, Susan E
AU  - Hankinson SE
LA  - eng
GR  - CA49449/CA/NCI NIH HHS/United States
GR  - P01 CA87969/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Obesity (Silver Spring)
JT  - Obesity (Silver Spring, Md.)
JID - 101264860
RN  - 0 (Adiponectin)
RN  - 0 (C-Peptide)
RN  - 0 (Gonadal Steroid Hormones)
RN  - 0 (Insulin-Like Growth Factor Binding Protein 1)
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 0 (Sex Hormone-Binding Globulin)
RN  - 0 (Somatomedins)
RN  - 2DI9HA706A (Estrone)
RN  - 3XMK78S47O (Testosterone)
RN  - 409J2J96VR (Androstenedione)
RN  - 459AG36T1B (Dehydroepiandrosterone)
RN  - 4TI98Z838E (Estradiol)
RN  - 9002-62-4 (Prolactin)
RN  - QTL48N278K (estrone sulfate)
SB  - IM
MH  - Adiponectin/*blood/metabolism
MH  - Aged
MH  - Androstenedione/metabolism
MH  - C-Peptide/*metabolism
MH  - Dehydroepiandrosterone/metabolism
MH  - Estradiol/metabolism
MH  - Estrone/analogs & derivatives/metabolism
MH  - Female
MH  - Gonadal Steroid Hormones/*metabolism
MH  - Humans
MH  - Insulin-Like Growth Factor Binding Protein 1/*metabolism
MH  - Insulin-Like Growth Factor Binding Protein 3/metabolism
MH  - Middle Aged
MH  - Prolactin/metabolism
MH  - Sex Hormone-Binding Globulin/*metabolism
MH  - Somatomedins/*metabolism
MH  - Testosterone/metabolism
EDAT- 2007/09/25 09:00
MHDA- 2008/01/11 09:00
CRDT- 2007/09/25 09:00
PHST- 2007/09/25 09:00 [pubmed]
PHST- 2008/01/11 09:00 [medline]
PHST- 2007/09/25 09:00 [entrez]
AID - 15/9/2217 [pii]
AID - 10.1038/oby.2007.263 [doi]
PST - ppublish
SO  - Obesity (Silver Spring). 2007 Sep;15(9):2217-24. doi: 10.1038/oby.2007.263.