PMID- 17890727
OWN - NLM
STAT- MEDLINE
DCOM- 20080123
LR  - 20210209
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 282
IP  - 47
DP  - 2007 Nov 23
TI  - The role of brain-derived neurotrophic factor (BDNF)-induced XBP1 splicing during 
      brain development.
PG  - 34525-34
AB  - Accumulation of unfolded proteins in the endoplasmic reticulum initiates 
      intracellular signaling termed the unfolded protein response (UPR). Although Xbp1 
      serves as a pivotal transcription factor for the UPR, the physiological role of 
      UPR signaling and Xbp1 in the central nervous system remains to be elucidated. 
      Here, we show that Xbp1 mRNA was highly expressed during neurodevelopment and 
      activated Xbp1 protein was distributed throughout developing neurons, including 
      neurites. The isolated neurite culture system and time-lapse imaging demonstrated 
      that Xbp1 was activated in neurites in response to brain-derived neurotrophic 
      factor (BDNF), followed by subsequent translocation of the active Xbp1 into the 
      nucleus. BDNF-dependent neurite outgrowth was significantly attenuated in 
      Xbp1(-/-) neurons. These findings suggest that BDNF initiates UPR signaling in 
      neurites and that Xbp1, which is activated as part of the UPR, conveys the local 
      information from neurites to the nucleus, contributing the neurite outgrowth.
FAU - Hayashi, Akiko
AU  - Hayashi A
AD  - Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute 
      RIKEN, Hirosawa, Wako-shi, Saitama, Japan.
FAU - Kasahara, Takaoki
AU  - Kasahara T
FAU - Iwamoto, Kazuya
AU  - Iwamoto K
FAU - Ishiwata, Mizuho
AU  - Ishiwata M
FAU - Kametani, Mizue
AU  - Kametani M
FAU - Kakiuchi, Chihiro
AU  - Kakiuchi C
FAU - Furuichi, Teiichi
AU  - Furuichi T
FAU - Kato, Tadafumi
AU  - Kato T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070921
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Regulatory Factor X Transcription Factors)
RN  - 0 (Transcription Factors)
RN  - 0 (X-Box Binding Protein 1)
RN  - 0 (Xbp1 protein, mouse)
SB  - IM
MH  - Active Transport, Cell Nucleus/physiology
MH  - Animals
MH  - Brain/*embryology
MH  - Brain-Derived Neurotrophic Factor/*metabolism/pharmacology
MH  - Cell Nucleus/genetics/*metabolism
MH  - Cells, Cultured
MH  - DNA-Binding Proteins/genetics/*metabolism
MH  - Mice
MH  - Mice, Knockout
MH  - Neurites/metabolism
MH  - Nuclear Proteins/genetics/*metabolism
MH  - *Protein Folding
MH  - RNA Splicing/*physiology
MH  - Regulatory Factor X Transcription Factors
MH  - Signal Transduction/drug effects/*physiology
MH  - Transcription Factors
MH  - X-Box Binding Protein 1
EDAT- 2007/09/25 09:00
MHDA- 2008/01/24 09:00
CRDT- 2007/09/25 09:00
PHST- 2007/09/25 09:00 [pubmed]
PHST- 2008/01/24 09:00 [medline]
PHST- 2007/09/25 09:00 [entrez]
AID - S0021-9258(20)54505-5 [pii]
AID - 10.1074/jbc.M704300200 [doi]
PST - ppublish
SO  - J Biol Chem. 2007 Nov 23;282(47):34525-34. doi: 10.1074/jbc.M704300200. Epub 2007 
      Sep 21.