PMID- 17890744
OWN - NLM
STAT- MEDLINE
DCOM- 20080715
LR  - 20080207
IS  - 1460-2385 (Electronic)
IS  - 0931-0509 (Linking)
VI  - 23
IP  - 2
DP  - 2008 Feb
TI  - Nocturnal haemodialysis increases pharyngeal size in patients with sleep apnoea 
      and end-stage renal disease.
PG  - 673-9
AB  - BACKGROUND: Sleep apnoea is common in patients with end-stage renal disease 
      (ESRD) and is improved by nocturnal haemodialysis (NHD). Recent findings from our 
      laboratory indicate the development of ESRD is associated with pharyngeal 
      narrowing. We hypothesized that NHD increases pharyngeal cross-sectional area and 
      that this is associated with an improvement in sleep apnoea. METHODS: Twenty-four 
      patients (aged 32-68 years), receiving conventional haemodialysis (CHD) (4 h/day, 
      3 days/week), were recruited for overnight polysomnography and estimation of 
      pharyngeal cross-sectional area at functional residual capacity (FRC) and 
      residual volume (RV). Patients were divided into apnoeic and non-apnoeic groups 
      based on an apnoea-hypopnoea index (AHI) > or = 15/h. Following conversion from 
      CHD to NHD (8 h/night, 3-6 nights/week) all measurements were repeated and 
      apnoeic patients were classified as 'responders' if AHI fell to < 15 events/h. 
      RESULTS: Conversion from CHD to NHD was associated with an increase in pharyngeal 
      cross-sectional area (FRC: 3.29 +/- 0.67 vs 3.39 +/- 0.75 cm(2); RV: 1.91 +/- 
      0.51 vs 2.13 +/- 0.48 cm(2), P < 0.05), which was not significantly different 
      between groups. Sleep apnoea improved in three patients. CONCLUSIONS: Conversion 
      from CHD to NHD is associated with an increase in pharyngeal cross-sectional 
      area. This may play a role in some patients whose sleep apnoea improves on NHD.
FAU - Beecroft, Jaime M
AU  - Beecroft JM
AD  - Department of Medicine, University of Calgary, Alberta, Canada.
FAU - Hoffstein, Victor
AU  - Hoffstein V
FAU - Pierratos, Andreas
AU  - Pierratos A
FAU - Chan, Christopher T
AU  - Chan CT
FAU - McFarlane, Philip
AU  - McFarlane P
FAU - Hanly, Patrick J
AU  - Hanly PJ
LA  - eng
PT  - Journal Article
DEP - 20070922
PL  - England
TA  - Nephrol Dial Transplant
JT  - Nephrology, dialysis, transplantation : official publication of the European 
      Dialysis and Transplant Association - European Renal Association
JID - 8706402
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Kidney Failure, Chronic/*complications/*therapy
MH  - Male
MH  - Middle Aged
MH  - Organ Size
MH  - Pharynx/*pathology
MH  - Renal Dialysis/*methods
MH  - Sleep Apnea Syndromes/*complications/*therapy
EDAT- 2007/09/25 09:00
MHDA- 2008/07/17 09:00
CRDT- 2007/09/25 09:00
PHST- 2007/09/25 09:00 [pubmed]
PHST- 2008/07/17 09:00 [medline]
PHST- 2007/09/25 09:00 [entrez]
AID - gfm598 [pii]
AID - 10.1093/ndt/gfm598 [doi]
PST - ppublish
SO  - Nephrol Dial Transplant. 2008 Feb;23(2):673-9. doi: 10.1093/ndt/gfm598. Epub 2007 
      Sep 22.