PMID- 17891348
OWN - NLM
STAT- MEDLINE
DCOM- 20080107
LR  - 20181113
IS  - 1342-1751 (Print)
IS  - 1342-1751 (Linking)
VI  - 11
IP  - 3
DP  - 2007 Sep
TI  - The characteristics of relapse in adult-onset minimal-change nephrotic syndrome.
PG  - 214-217
LID - 10.1007/s10157-007-0484-5 [doi]
AB  - BACKGROUND: Although minimal-change nephrotic syndrome (MCNS) is highly 
      steroid-responsive, the frequency of relapses in some patients is high, 
      necessitating the administration of repeated courses of prednisolone in high 
      doses. It is, therefore, necessary to identify factors that can predict this 
      increased risk of relapse in some patients in order to establish useful treatment 
      methods to reduce the risk. METHODS: To clarify the factors that might increase 
      the risk of relapses, the data of 82 Japanese adult patients with MCNS receiving 
      treatment at our department were analyzed retrospectively. Of the total, 55 
      patients (67.1%) experienced relapse after showing an initial response. We 
      divided the patients into two groups; namely, the nonrelapse group (n = 27) and 
      the relapse group (n = 55), and compared the clinico-pathophysiological 
      characteristics between the two groups. RESULTS: Significantly increased serum 
      immunoglobulin E (IgE) levels (P = 0.0002) and increased frequency of steroid 
      side effects were observed in the relapse group as compared to the nonrelapse 
      group. CONCLUSIONS: To develop effective therapeutic modalities, it is important 
      to have a thorough understanding of the clinico-pathophysiological 
      characteristics of MCNS patients showing relapse.
FAU - Takei, Takashi
AU  - Takei T
AD  - Department of Medicine, Kidney Center, Tokyo Women's Medical University, 8-1 
      Kawadacho, Shinjuku-ku, Tokyo, 162-8666, Japan. ttakei@kc.twmu.ac.jp.
FAU - Koike, Minako
AU  - Koike M
AD  - Department of Medicine, Kidney Center, Tokyo Women's Medical University, 8-1 
      Kawadacho, Shinjuku-ku, Tokyo, 162-8666, Japan.
FAU - Suzuki, Koichi
AU  - Suzuki K
AD  - Department of Medicine, Kidney Center, Tokyo Women's Medical University, 8-1 
      Kawadacho, Shinjuku-ku, Tokyo, 162-8666, Japan.
FAU - Shirota, Satsuki
AU  - Shirota S
AD  - Department of Medicine, Kidney Center, Tokyo Women's Medical University, 8-1 
      Kawadacho, Shinjuku-ku, Tokyo, 162-8666, Japan.
FAU - Itabashi, Mitsuyo
AU  - Itabashi M
AD  - Department of Medicine, Kidney Center, Tokyo Women's Medical University, 8-1 
      Kawadacho, Shinjuku-ku, Tokyo, 162-8666, Japan.
FAU - Ohtsubo, Shigeru
AU  - Ohtsubo S
AD  - Department of Medicine, Kidney Center, Tokyo Women's Medical University, 8-1 
      Kawadacho, Shinjuku-ku, Tokyo, 162-8666, Japan.
FAU - Sugiura, Hidekazu
AU  - Sugiura H
AD  - Department of Medicine, Kidney Center, Tokyo Women's Medical University, 8-1 
      Kawadacho, Shinjuku-ku, Tokyo, 162-8666, Japan.
FAU - Suzuki, Keiko
AU  - Suzuki K
AD  - Department of Medicine, Kidney Center, Tokyo Women's Medical University, 8-1 
      Kawadacho, Shinjuku-ku, Tokyo, 162-8666, Japan.
FAU - Kojima, Chiari
AU  - Kojima C
AD  - Department of Medicine, Kidney Center, Tokyo Women's Medical University, 8-1 
      Kawadacho, Shinjuku-ku, Tokyo, 162-8666, Japan.
FAU - Takahashi, Masaki
AU  - Takahashi M
AD  - Department of Medicine, Kidney Center, Tokyo Women's Medical University, 8-1 
      Kawadacho, Shinjuku-ku, Tokyo, 162-8666, Japan.
FAU - Ino, Jun
AU  - Ino J
AD  - Department of Medicine, Kidney Center, Tokyo Women's Medical University, 8-1 
      Kawadacho, Shinjuku-ku, Tokyo, 162-8666, Japan.
FAU - Ogawa, Tetsuya
AU  - Ogawa T
AD  - Department of Medicine, Kidney Center, Tokyo Women's Medical University, 8-1 
      Kawadacho, Shinjuku-ku, Tokyo, 162-8666, Japan.
FAU - Uchida, Keiko
AU  - Uchida K
AD  - Department of Medicine, Kidney Center, Tokyo Women's Medical University, 8-1 
      Kawadacho, Shinjuku-ku, Tokyo, 162-8666, Japan.
FAU - Tsuchiya, Ken
AU  - Tsuchiya K
AD  - Department of Medicine, Kidney Center, Tokyo Women's Medical University, 8-1 
      Kawadacho, Shinjuku-ku, Tokyo, 162-8666, Japan.
FAU - Yumura, Wako
AU  - Yumura W
AD  - Department of Medicine, Kidney Center, Tokyo Women's Medical University, 8-1 
      Kawadacho, Shinjuku-ku, Tokyo, 162-8666, Japan.
FAU - Nitta, Kosaku
AU  - Nitta K
AD  - Department of Medicine, Kidney Center, Tokyo Women's Medical University, 8-1 
      Kawadacho, Shinjuku-ku, Tokyo, 162-8666, Japan.
LA  - eng
PT  - Journal Article
DEP - 20070928
PL  - Japan
TA  - Clin Exp Nephrol
JT  - Clinical and experimental nephrology
JID - 9709923
RN  - 0 (Glucocorticoids)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9PHQ9Y1OLM (Prednisolone)
SB  - IM
MH  - Adult
MH  - Female
MH  - Glucocorticoids/adverse effects/*therapeutic use
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Middle Aged
MH  - Nephrosis, Lipoid/blood/drug therapy/*physiopathology
MH  - Prednisolone/adverse effects/*therapeutic use
MH  - Recurrence
MH  - Retrospective Studies
EDAT- 2007/09/25 09:00
MHDA- 2008/01/08 09:00
CRDT- 2007/09/25 09:00
PHST- 2007/03/20 00:00 [received]
PHST- 2007/06/11 00:00 [accepted]
PHST- 2007/09/25 09:00 [pubmed]
PHST- 2008/01/08 09:00 [medline]
PHST- 2007/09/25 09:00 [entrez]
AID - 10.1007/s10157-007-0484-5 [pii]
AID - 10.1007/s10157-007-0484-5 [doi]
PST - ppublish
SO  - Clin Exp Nephrol. 2007 Sep;11(3):214-217. doi: 10.1007/s10157-007-0484-5. Epub 
      2007 Sep 28.