PMID- 17891349
OWN - NLM
STAT- MEDLINE
DCOM- 20080107
LR  - 20181113
IS  - 1342-1751 (Print)
IS  - 1342-1751 (Linking)
VI  - 11
IP  - 3
DP  - 2007 Sep
TI  - Reduction of serum antioxidative capacity during hemodialysis.
PG  - 218-224
LID - 10.1007/s10157-007-0486-3 [doi]
AB  - BACKGROUND: Hemodialysis (HD) is thought to exacerbate oxidative stress (OS). The 
      purpose of this study was to assess patients' oxidative status during and after 
      HD, and to clarify the relation between oxidative status and antioxidant solutes 
      such as uric acid (UA) and ascorbic acid (AsA). METHODS: Serum diacron-reactive 
      oxygen metabolites (d-ROM), and biological antioxidant potential (BAP), as well 
      as serum concentrations of UA, AsA, urea nitrogen (UN), and creatinine (Cre) were 
      measured in eight HD patients at six time points during and after HD. Inflow and 
      outflow dialyzer blood was evaluated during HD or sham HD (no dialysate flow). 
      Further, BAP was evaluated by adding UA or AsA to post-HD serum. RESULTS: No 
      changes were found in d-ROM over time, whereas BAP was significantly decreased by 
      HD. No differences were found in d-ROM during HD or sham HD, or between inflow 
      and outflow blood. During HD, significantly lower BAP levels were found in 
      outflow blood than in inflow blood. Serum UA and AsA levels were decreased by HD; 
      however, no increases were observed in BAP levels after the addition of these 
      molecules to post-HD serum. CONCLUSION: These data indicate that HD reduces serum 
      antioxidative capacity, and the loss of dialyzable molecules may be involved. 
      However, this reduction in capacity does not seem to be caused by the loss of UA 
      or AsA.
FAU - Nakayama, Keisuke
AU  - Nakayama K
AD  - Research Division of Dialysis and Chronic Kidney Disease, Tohoku University 
      Graduate School of Medicine, 1-1 Seiryo machi aoba-ku, Sendai, 980-8574, Japan. 
      nkeisuke@ac.cyberhome.ne.jp.
FAU - Terawaki, Hiroyuki
AU  - Terawaki H
AD  - Research Division of Dialysis and Chronic Kidney Disease, Tohoku University 
      Graduate School of Medicine, 1-1 Seiryo machi aoba-ku, Sendai, 980-8574, Japan.
FAU - Nakayama, Masaaki
AU  - Nakayama M
AD  - Research Division of Dialysis and Chronic Kidney Disease, Tohoku University 
      Graduate School of Medicine, 1-1 Seiryo machi aoba-ku, Sendai, 980-8574, Japan.
FAU - Iwabuchi, Masashi
AU  - Iwabuchi M
AD  - Department of Blood Purification, Tohoku University Graduate School of Medicine, 
      Sendai, Japan.
FAU - Sato, Toshinobu
AU  - Sato T
AD  - Department of Blood Purification, Tohoku University Graduate School of Medicine, 
      Sendai, Japan.
FAU - Ito, Sadayoshi
AU  - Ito S
AD  - Research Division of Dialysis and Chronic Kidney Disease, Tohoku University 
      Graduate School of Medicine, 1-1 Seiryo machi aoba-ku, Sendai, 980-8574, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070928
PL  - Japan
TA  - Clin Exp Nephrol
JT  - Clinical and experimental nephrology
JID - 9709923
RN  - 0 (Antioxidants)
RN  - 268B43MJ25 (Uric Acid)
RN  - PQ6CK8PD0R (Ascorbic Acid)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antioxidants/*metabolism
MH  - Ascorbic Acid/*blood
MH  - Cross-Over Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oxidative Stress/*physiology
MH  - Renal Dialysis/*adverse effects
MH  - Uric Acid/*blood
EDAT- 2007/09/25 09:00
MHDA- 2008/01/08 09:00
CRDT- 2007/09/25 09:00
PHST- 2006/12/13 00:00 [received]
PHST- 2007/06/18 00:00 [accepted]
PHST- 2007/09/25 09:00 [pubmed]
PHST- 2008/01/08 09:00 [medline]
PHST- 2007/09/25 09:00 [entrez]
AID - 10.1007/s10157-007-0486-3 [pii]
AID - 10.1007/s10157-007-0486-3 [doi]
PST - ppublish
SO  - Clin Exp Nephrol. 2007 Sep;11(3):218-224. doi: 10.1007/s10157-007-0486-3. Epub 
      2007 Sep 28.