PMID- 17892630
OWN - NLM
STAT- MEDLINE
DCOM- 20080904
LR  - 20220316
IS  - 0950-2688 (Print)
IS  - 1469-4409 (Electronic)
IS  - 0950-2688 (Linking)
VI  - 136
IP  - 8
DP  - 2008 Aug
TI  - Emergence of increasing linezolid-resistance in enterococci in a post-outbreak 
      situation with vancomycin-resistant Enterococcus faecium.
PG  - 1131-3
AB  - During 2004 and at the start of 2005 a university hospital in Southwest Germany 
      was affected by an extensive outbreak of vancomycin-resistant Enterococcus 
      faecium (VRE). Although the outbreak was contained, linezolid-resistant 
      enterococci emerged during and after the outbreak as the usage of linezolid 
      became more common. Linezolid resistance was no longer limited to VRE. Nosocomial 
      spread of linezolid-resistant but vancomycin-susceptible E. faecium was detected 
      and these strains also emerged in patients without prior drug exposure. Linezolid 
      should therefore be used with caution and the susceptibility of isolates 
      monitored over time. Isolation precautions and screening of contacts should be 
      considered to avoid spread of resistant isolates.
FAU - Schulte, B
AU  - Schulte B
AD  - Institut fur Medizinische Mikrobiologie und Hygiene, Eberhard-Karls-Universitat, 
      Tubingen, Germany. berit.schulte@med.uni-tuebingen.de
FAU - Heininger, A
AU  - Heininger A
FAU - Autenrieth, I B
AU  - Autenrieth IB
FAU - Wolz, C
AU  - Wolz C
LA  - eng
PT  - Journal Article
DEP - 20070925
PL  - England
TA  - Epidemiol Infect
JT  - Epidemiology and infection
JID - 8703737
RN  - 0 (Acetamides)
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Oxazolidinones)
RN  - 0 (Protein Synthesis Inhibitors)
RN  - ISQ9I6J12J (Linezolid)
SB  - IM
MH  - Acetamides/*pharmacology
MH  - Anti-Bacterial Agents/pharmacology
MH  - Disease Outbreaks
MH  - Drug Resistance, Bacterial
MH  - Enterococcus faecium/*drug effects/isolation & purification
MH  - Germany/epidemiology
MH  - Hospitals, University
MH  - Humans
MH  - Linezolid
MH  - Microbial Sensitivity Tests
MH  - Oxazolidinones/*pharmacology
MH  - Protein Synthesis Inhibitors/*pharmacology
MH  - Vancomycin Resistance
PMC - PMC2870893
EDAT- 2007/09/26 09:00
MHDA- 2008/09/05 09:00
PMCR- 2009/08/01
CRDT- 2007/09/26 09:00
PHST- 2007/09/26 09:00 [pubmed]
PHST- 2008/09/05 09:00 [medline]
PHST- 2007/09/26 09:00 [entrez]
PHST- 2009/08/01 00:00 [pmc-release]
AID - S0950268807009508 [pii]
AID - 00950 [pii]
AID - 10.1017/S0950268807009508 [doi]
PST - ppublish
SO  - Epidemiol Infect. 2008 Aug;136(8):1131-3. doi: 10.1017/S0950268807009508. Epub 
      2007 Sep 25.