PMID- 17893397
OWN - NLM
STAT- MEDLINE
DCOM- 20071220
LR  - 20200304
IS  - 1096-6080 (Print)
IS  - 1096-0929 (Linking)
VI  - 100
IP  - 2
DP  - 2007 Dec
TI  - Alteration of neurotrophins in the hippocampus and cerebral cortex of young rats 
      exposed to chlorpyrifos and methyl parathion.
PG  - 445-55
AB  - Exposure to either chlorpyrifos (CPS) or methyl parathion (MPS) results in the 
      inhibition of acetylcholinesterase and leads to altered neuronal activity which 
      normally regulates critical genes such as the neurotrophins nerve growth factor 
      (NGF) and brain-derived neurotrophic factor (BDNF). The effects of postnatal 
      exposure to CPS and MPS on the expression of messenger RNA (mRNA) and protein 
      levels for NGF and BDNF were investigated in the frontal cerebral cortex (cortex) 
      and hippocampus of rats. Oral administration of CPS (4.0 or 6.0 mg/kg), MPS (0.6 
      or 0.9 mg/kg), or the safflower oil vehicle was performed daily from postnatal 
      day 10 (PND10) through PND20. Exposure induced significant effects on growth and 
      cholinesterase activity. Increased NGF protein levels were observed in the 
      hippocampus but not the cortex on PND20 with some reduction occurring on PND28 in 
      both regions. These changes did not correlate with the changes in NGF mRNA. BDNF 
      mRNA was increased in both regions on PND20 and PND28, whereas BDNF protein 
      levels were increased on PND20. On PND12, c-fos mRNA, a marker of neuronal 
      activation, was increased in both regions. Total BDNF protein was increased in 
      the hippocampus but decreased in the cortex. No changes in NGF protein were 
      observed. These results indicate that repeated developmental OP exposure during 
      the postnatal period alters NGF and BDNF in the cortex and the hippocampus and 
      the patterns of these alterations differ between regions.
FAU - Betancourt, Angela M
AU  - Betancourt AM
AD  - Center for Environmental Health Sciences, College of Veterinary Medicine, 
      Mississippi State University, Mississippi State, MS 39762, USA.
FAU - Filipov, Nikolay M
AU  - Filipov NM
FAU - Carr, Russell L
AU  - Carr RL
LA  - eng
GR  - P20 RR017661/RR/NCRR NIH HHS/United States
GR  - 1 P20 RR17661/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20070924
PL  - United States
TA  - Toxicol Sci
JT  - Toxicological sciences : an official journal of the Society of Toxicology
JID - 9805461
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cholinesterase Inhibitors)
RN  - 0 (Insecticides)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 41BCL2O91D (Methyl Parathion)
RN  - JCS58I644W (Chlorpyrifos)
SB  - IM
MH  - Animals
MH  - Animals, Suckling
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Cerebral Cortex/*drug effects/metabolism
MH  - Chlorpyrifos/*toxicity
MH  - Cholinesterase Inhibitors/*toxicity
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Gene Expression
MH  - Gene Expression Regulation, Developmental/drug effects
MH  - Hippocampus/*drug effects/metabolism
MH  - Insecticides/*toxicity
MH  - Male
MH  - Methyl Parathion/*toxicity
MH  - Nerve Growth Factors/genetics/*metabolism
MH  - Proto-Oncogene Proteins c-fos/genetics/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2007/09/26 09:00
MHDA- 2007/12/21 09:00
CRDT- 2007/09/26 09:00
PHST- 2007/09/26 09:00 [pubmed]
PHST- 2007/12/21 09:00 [medline]
PHST- 2007/09/26 09:00 [entrez]
AID - kfm248 [pii]
AID - 10.1093/toxsci/kfm248 [doi]
PST - ppublish
SO  - Toxicol Sci. 2007 Dec;100(2):445-55. doi: 10.1093/toxsci/kfm248. Epub 2007 Sep 
      24.