PMID- 17893607
OWN - NLM
STAT- MEDLINE
DCOM- 20071101
LR  - 20070925
IS  - 0041-1337 (Print)
IS  - 0041-1337 (Linking)
VI  - 84
IP  - 6
DP  - 2007 Sep 27
TI  - Antibodies against donor human leukocyte antigens and the outcome of cardiac 
      allografts in adults and children.
PG  - 738-45
AB  - BACKGROUND: Mismatched histocompatibility antigens between donor organ and host 
      stimulate the immune response that causes allograft rejection. Antibodies against 
      human leukocyte antigen (HLA) are known to appear in the serum of heart 
      transplant recipients. METHODS: We have tested stored sera with HLA bound to 
      polystyrene microbeads in a retrospective analysis of heart recipients 
      transplanted in our center to better understand the impact of antibodies against 
      HLA on the posttransplant course. Our analysis included two groups of patients: 
      113 adults and 31 children who received consecutive heart transplants performed 
      between 1996 and 2003. RESULTS: Presence of HLA antibodies, especially when 
      donor-specific, as determined with single HLA class I or class II beads, was 
      associated with more frequent occurrence of acute rejection, development of 
      transplant-related coronary artery disease and decreased graft survival. 
      Recipients having antibodies only to HLA not in the transplant and those without 
      any HLA antibodies had similar outcomes, suggesting that antibodies against 
      antigens not present on the donor organ did not harm the graft. CONCLUSION: The 
      results showed that presence of antibodies against HLA of the donor correlated 
      with graft loss and suggested that testing for these antibodies may help in the 
      management of heart transplant patients.
FAU - Stastny, Peter
AU  - Stastny P
AD  - Department of Internal Medicine, University of Texas Southwestern Medical Center, 
      Dallas, TX 75390-8886, USA. peter.stastny@utsouthwestern.edu
FAU - Lavingia, Bhavna
AU  - Lavingia B
FAU - Fixler, David E
AU  - Fixler DE
FAU - Yancy, Clyde W
AU  - Yancy CW
FAU - Ring, W Steves
AU  - Ring WS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - 0 (Antibodies)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antibodies/*blood
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Graft Rejection/*diagnosis
MH  - Graft Survival
MH  - HLA Antigens/*immunology
MH  - *Heart Transplantation
MH  - Humans
MH  - Infant
MH  - Male
MH  - Middle Aged
MH  - Tissue Donors
MH  - Treatment Outcome
EDAT- 2007/09/26 09:00
MHDA- 2007/11/02 09:00
CRDT- 2007/09/26 09:00
PHST- 2007/09/26 09:00 [pubmed]
PHST- 2007/11/02 09:00 [medline]
PHST- 2007/09/26 09:00 [entrez]
AID - 00007890-200709270-00012 [pii]
AID - 10.1097/01.tp.0000281918.51138.3f [doi]
PST - ppublish
SO  - Transplantation. 2007 Sep 27;84(6):738-45. doi: 
      10.1097/01.tp.0000281918.51138.3f.