PMID- 17894414
OWN - NLM
STAT- MEDLINE
DCOM- 20080723
LR  - 20221207
IS  - 1552-485X (Electronic)
IS  - 1552-4841 (Print)
IS  - 1552-4841 (Linking)
VI  - 147B
IP  - 4
DP  - 2008 Jun 5
TI  - BDNF Val66Met variant and age of onset in schizophrenia.
PG  - 505-6
AB  - Brain-derived neurotrophic factor (BDNF) has been advanced as a candidate gene 
      for schizophrenia by virtue of its effects on neurotransmitter systems that are 
      dysregulated in psychiatric disorder and its involvement in the response to 
      antipsychotic drugs. The extensively examined BDNF gene Val66Met (or rs6265) 
      variant has been associated with schizophrenia, and studies have linked this 
      polymorphism to brain morphology, cognitive function, and psychiatric symptoms in 
      schizophrenia. Moreover the BDNF Val66Met variant has been reported to be 
      associated with age of onset in schizophrenia. Genotyping of African-American 
      subjects with schizophrenia for five BDNF coding region single nucleotide 
      polymorphisms revealed variance only at the Val66Met allele. The results of 
      statistical analyses indicate a relationship between the BDNF Val66Met genotype 
      and the ages of first psychiatric hospitalization and first schizophrenia 
      symptoms.
CI  - (c) 2007 Wiley-Liss, Inc.
FAU - Chao, Helen M
AU  - Chao HM
AD  - Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA. 
      chaoh@nki.rfmh.org
FAU - Kao, Hung-Teh
AU  - Kao HT
FAU - Porton, Barbara
AU  - Porton B
LA  - eng
GR  - R01 MH070898/MH/NIMH NIH HHS/United States
GR  - R01 MH070898-04/MH/NIMH NIH HHS/United States
GR  - R03 MH062352-01/MH/NIMH NIH HHS/United States
GR  - R03 MH062352/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Am J Med Genet B Neuropsychiatr Genet
JT  - American journal of medical genetics. Part B, Neuropsychiatric genetics : the 
      official publication of the International Society of Psychiatric Genetics
JID - 101235742
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Black or African American/genetics
MH  - *Age of Onset
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Genotype
MH  - Humans
MH  - Mutation, Missense
MH  - *Polymorphism, Single Nucleotide
MH  - Schizophrenia/ethnology/*genetics
PMC - PMC2396782
MID - NIHMS37414
EDAT- 2007/09/27 09:00
MHDA- 2008/07/24 09:00
PMCR- 2008/06/05
CRDT- 2007/09/27 09:00
PHST- 2007/09/27 09:00 [pubmed]
PHST- 2008/07/24 09:00 [medline]
PHST- 2007/09/27 09:00 [entrez]
PHST- 2008/06/05 00:00 [pmc-release]
AID - 10.1002/ajmg.b.30619 [doi]
PST - ppublish
SO  - Am J Med Genet B Neuropsychiatr Genet. 2008 Jun 5;147B(4):505-6. doi: 
      10.1002/ajmg.b.30619.