PMID- 17896122
OWN - NLM
STAT- MEDLINE
DCOM- 20080131
LR  - 20191210
IS  - 1018-8827 (Print)
IS  - 1018-8827 (Linking)
VI  - 16
IP  - 7
DP  - 2007 Oct
TI  - The Maudsley early onset schizophrenia study. Predictors of psychosocial outcome 
      at 4-year follow-up.
PG  - 465-70
AB  - OBJECTIVE: To examine the contribution of premorbid function, duration of 
      untreated psychosis (DUP), age of onset, severity of symptoms at presentation, 
      and number of subsequent hospitalisations to the outcome of early onset 
      schizophrenia (EOS; onset before 17th birthday). METHOD: Twenty-three EOS 
      patients (mean age at onset 15.16 +/- 1.39 years) were re-assessed after a mean 
      interval of 4 +/- 1.08 years. At baseline and follow-up clinical diagnoses were 
      confirmed using the Structured Clinical Interview for DSM-IV Axis I Disorders and 
      symptoms were assessed with the Positive and Negative Syndrome Scale. Premorbid 
      function, as measured with the Premorbid Adjustment Scale, age of onset and DUP 
      were assessed at baseline only. Outcome was evaluated using the Social Adaptation 
      Self-Evaluation Scale (SASS) and the Global Assessment of Functioning (GAF) 
      Scale. RESULTS: Mean DUP was 2.95 +/- 3.59 months and mean total PAS score was 
      6.65 +/- 3.02. They had an average of 2.09 +/- 1.44 hospitalisations and their 
      mean SASS and GAF scores were 37.27 +/- 6.5 and 54.19 +/- 18.99, respectively. 
      Poor childhood premorbid function and the severity of negative symptoms at 
      baseline were correlated with worse SASS and GAF scores. No other significant 
      associations were found. CONCLUSIONS: Poor childhood function is the most 
      significant predictor of outcome in EOS.
FAU - Vyas, Nora S
AU  - Vyas NS
AD  - Section of Neurobiology of Psychosis, Institute of Psychiatry, London, UK.
FAU - Hadjulis, Michael
AU  - Hadjulis M
FAU - Vourdas, Apostolos
AU  - Vourdas A
FAU - Byrne, Patrick
AU  - Byrne P
FAU - Frangou, Sophia
AU  - Frangou S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Eur Child Adolesc Psychiatry
JT  - European child & adolescent psychiatry
JID - 9212296
SB  - IM
MH  - *Adaptation, Psychological
MH  - Adolescent
MH  - Adult
MH  - Age of Onset
MH  - Child
MH  - Child Behavior/psychology
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Outcome Assessment, Health Care
MH  - Patient Readmission/statistics & numerical data
MH  - Prognosis
MH  - Psychiatric Status Rating Scales/statistics & numerical data
MH  - Psychology, Adolescent
MH  - Psychology, Child
MH  - Schizophrenia/*diagnosis
MH  - *Schizophrenic Psychology
MH  - Severity of Illness Index
MH  - Sex Distribution
MH  - *Social Adjustment
MH  - Time Factors
EDAT- 2007/09/27 09:00
MHDA- 2008/02/01 09:00
CRDT- 2007/09/27 09:00
PHST- 2007/03/29 00:00 [accepted]
PHST- 2007/09/27 09:00 [pubmed]
PHST- 2008/02/01 09:00 [medline]
PHST- 2007/09/27 09:00 [entrez]
AID - 10.1007/s00787-007-0621-4 [doi]
PST - ppublish
SO  - Eur Child Adolesc Psychiatry. 2007 Oct;16(7):465-70. doi: 
      10.1007/s00787-007-0621-4.