PMID- 17896346 OWN - NLM STAT- MEDLINE DCOM- 20080117 LR - 20131121 IS - 0885-6222 (Print) IS - 0885-6222 (Linking) VI - 22 IP - 7 DP - 2007 Oct TI - The neuropsychology of ecstasy (MDMA) use: a quantitative review. PG - 427-35 AB - A growing number of empirical studies have found varying neuropsychological impairments associated with use of 3,4-methylenedioxymethamphetamine (MDMA) use. We set out to determine to what extent neuropsychological abilities are impaired in MDMA users. To do so, meta-analytical methods were used to determine the magnitude of neuropsychological impairment in MDMA users across pre-specified cognitive domains. We found that cognitive impairment secondary to recreational drug use may result in what might be described as small-to-medium effects across all cognitive domains with learning and memory being most impaired. We also found that total lifetime ingestion of MDMA appears to be negatively associated with performance on tasks ranging from attention and concentration to learning and memory. Implications and limitations of these findings are discussed. CI - Copyright 2007 John Wiley & Sons, Ltd. FAU - Zakzanis, Konstantine K AU - Zakzanis KK AD - Department of Psychology, University of Toronto at Scarborough, Toronto, Ontario, Canada. zakzanis@utsc.utoronto.ca FAU - Campbell, Zachariah AU - Campbell Z FAU - Jovanovski, Diana AU - Jovanovski D LA - eng PT - Journal Article PT - Meta-Analysis PT - Review PL - England TA - Hum Psychopharmacol JT - Human psychopharmacology JID - 8702539 RN - 0 (Hallucinogens) RN - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine) SB - IM MH - Attention/drug effects MH - Cognition Disorders/*chemically induced MH - Hallucinogens/*adverse effects MH - Humans MH - Learning/drug effects MH - Memory/drug effects MH - N-Methyl-3,4-methylenedioxyamphetamine/*adverse effects MH - Neuropsychological Tests MH - Psychomotor Performance/drug effects RF - 71 EDAT- 2007/09/27 09:00 MHDA- 2008/01/18 09:00 CRDT- 2007/09/27 09:00 PHST- 2007/09/27 09:00 [pubmed] PHST- 2008/01/18 09:00 [medline] PHST- 2007/09/27 09:00 [entrez] AID - 10.1002/hup.873 [doi] PST - ppublish SO - Hum Psychopharmacol. 2007 Oct;22(7):427-35. doi: 10.1002/hup.873.