PMID- 17897735
OWN - NLM
STAT- MEDLINE
DCOM- 20081023
LR  - 20221207
IS  - 0167-4943 (Print)
IS  - 0167-4943 (Linking)
VI  - 47
IP  - 2
DP  - 2008 Sep-Oct
TI  - Trazodone for Alzheimer's disease: a naturalistic follow-up study.
PG  - 207-15
AB  - This study intended to provide a patient profile for trazodone (a 
      triazolopyridine-derivative of phenylpiperazine) prescription in everyday 
      clinical practice in patients with Alzheimer's disease (AD), and to describe 
      clinical evaluation and the impact on caregiver burden at a 6-month follow-up. A 
      naturalistic, prospective and observational study was performed, with a 6-month 
      follow-up in 396 patients with probable AD, according to the NINCDS-ARDRA 
      criteria. At the baseline and at the 6-month visit, patients were administered 
      the Neuropsychiatric Inventory (NPI) to determine their Behavioral and 
      Psychological Symptoms of Dementia (BPSD), and the Zarit Burden Interview (ZBI) 
      to assess the impact on caregiver burden. Trazodone was prescribed for 6.1% of 
      patients. With respect to the baseline visit, the untreated group showed an 
      increased global NPI score (3.1 points; 95% CI=1.9-4.2; p=0.001) and ZBI score 
      (2.2 points; 95% CI=0.9-3.4; p=0.001). At 6 months, the global NPI and ZBI scores 
      remained unchanged for the treated group. The treated group showed a significant 
      reduction in the NPI irritability subscale score (2.1 points; 95% CI=0.4-3.7; 
      p=0.015). In the clinical practice, trazodone treatment was prescribed for 
      patients with irritability, agitation and disinhibition. After 6 months, patients 
      treated with trazodone exhibited no increase in BPSD frequency or severity, nor 
      was an increase noted in the caregiver burden.
FAU - Lopez-Pousa, Secundino
AU  - Lopez-Pousa S
AD  - Research Unit, Institut d'Assistencia Sanitaria, Hospital Santa Caterina, Parc 
      Hospitalari Marti i Julia, C/Dr. Castany s/n, 17190 Salt, Girona, Spain. 
      uvamid@ias.scs.es
FAU - Garre-Olmo, Josep
AU  - Garre-Olmo J
FAU - Vilalta-Franch, Joan
AU  - Vilalta-Franch J
FAU - Turon-Estrada, Antoni
AU  - Turon-Estrada A
FAU - Pericot-Nierga, Imma
AU  - Pericot-Nierga I
LA  - eng
PT  - Journal Article
DEP - 20070925
PL  - Netherlands
TA  - Arch Gerontol Geriatr
JT  - Archives of gerontology and geriatrics
JID - 8214379
RN  - 0 (Serotonin Uptake Inhibitors)
RN  - YBK48BXK30 (Trazodone)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/complications/*drug therapy
MH  - Caregivers
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Mental Disorders/*drug therapy/etiology
MH  - Middle Aged
MH  - Selective Serotonin Reuptake Inhibitors/*therapeutic use
MH  - Trazodone/*therapeutic use
EDAT- 2007/09/28 09:00
MHDA- 2008/10/24 09:00
CRDT- 2007/09/28 09:00
PHST- 2007/02/07 00:00 [received]
PHST- 2007/07/12 00:00 [revised]
PHST- 2007/07/23 00:00 [accepted]
PHST- 2007/09/28 09:00 [pubmed]
PHST- 2008/10/24 09:00 [medline]
PHST- 2007/09/28 09:00 [entrez]
AID - S0167-4943(07)00176-8 [pii]
AID - 10.1016/j.archger.2007.07.010 [doi]
PST - ppublish
SO  - Arch Gerontol Geriatr. 2008 Sep-Oct;47(2):207-15. doi: 
      10.1016/j.archger.2007.07.010. Epub 2007 Sep 25.