PMID- 17900288
OWN - NLM
STAT- MEDLINE
DCOM- 20080515
LR  - 20211203
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 70
IP  - 6
DP  - 2007 Dec
TI  - HLA class I (A, B, C) and class II (DRB1, DQA1, DQB1, DPB1) alleles and 
      haplotypes in the Han from southern China.
PG  - 455-63
AB  - In this study, polymerase chain reaction-sequence-specific oligonucleotide prode 
      (SSOP) typing results for the human leukocyte antigen (HLA) class I (A, B, and C) 
      and class II (DRB1, DQA1, DQB1, and DPB1) loci in 264 individuals of the Han 
      ethnic group from the Canton region of southern China are presented. The data are 
      examined at the allele, genotype, and haplotype level. Common alleles at each of 
      the loci are in keeping with those observed in similar populations, while the 
      high-resolution typing methods used give additional details about allele 
      frequency distributions not shown in previous studies. Twenty distinct alleles 
      are seen at HLA-A in this population. The locus is dominated by the A*1101 
      allele, which is found here at a frequency of 0.266. The next three most common 
      alleles, A*2402, A*3303, and A*0203, are each seen at frequencies of greater than 
      10%, and together, these four alleles account for roughly two-thirds of the total 
      for HLA-A in this population. Fifty alleles are observed for HLA-B, 21 of which 
      are singleton copies. The most common HLA-B alleles are B*4001 (f= 0.144), B*4601 
      (f= 0.119), B*5801 (f= 0.089), B*1301 (f= 0.068), B*1502 (f= 0.073), and B*3802 
      (f= 0.070). At the HLA-C locus, there are a total of 20 alleles. Four alleles 
      (Cw*0702, Cw*0102, Cw*0801, and Cw*0304) are found at frequencies of greater than 
      10%, and together, these alleles comprise over 60% of the total. Overall, the 
      class II loci are somewhat less diverse than class I. Twenty-eight distinct 
      alleles are seen at DRB1, and the most common three, DRB1*0901, *1202, and *1501, 
      are each seen at frequencies of greater than 10%. The DR4 lineage also shows 
      extensive expansion in this population, with seven subtypes, representing one 
      quarter of the diversity at this locus. Eight alleles are observed at DQA1; 
      DQA1*0301 and 0102 are the most common alleles, with frequencies over 20%. The 
      DQB1 locus is dominated by four alleles of the 03 lineage, which make up nearly 
      half of the total. The two most common DQB1 alleles in this population are 
      DQB1*0301 (f= 0.242) and DQB1*0303 (f= 0.15). Eighteen alleles are observed at 
      DPB1; DPB1*0501 is the most common allele, with a frequency of 37%. The class I 
      allele frequency distributions, expressed in terms of Watterson's (homozygosity) 
      F-statistic, are all within expectations under neutrality, while there is 
      evidence for balancing selection at DRB1, DQA1, and DQB1. Departures from 
      Hardy-Weinberg expectations are observed for HLA-C and DRB1 in this population. 
      Strong individual haplotypic associations are seen for all pairs of loci, and 
      many of these occur at frequencies greater than 5%. In the class I region, 
      several examples of HLA-B and -C loci in complete or near complete linkage 
      disequilibrium (LD) are present, and the two most common, B*4601-Cw*0102 and 
      B*5801-Cw*0302 account for more than 20% of the B-C haplotypes. Similarly, at 
      class II, nearly all of the most common DR-DQ haplotypes are in nearly complete 
      LD. The most common DRB1-DQB1 haplotypes are DRB1*0901-DQB1*0303 (f= 0.144) and 
      DRB1*1202-DQB1*0301 (f= 0.131). The most common four locus class I and class II 
      combined haplotypes are A*3303-B*5801-DRB1*0301-DPB1*0401 (f= 0.028) and 
      A*0207-B*4601-DRB1*0901-DPB1*0501 (f= 0.026). The presentation of complete DNA 
      typing for the class I loci and haplotype analysis in a large sample such as this 
      can provide insights into the population history of the region and give useful 
      data for HLA matching in transplantation and disease association studies in the 
      Chinese population.
FAU - Trachtenberg, E
AU  - Trachtenberg E
AD  - Children's Hospital Oakland Research Institute, Oakland, CA 94609, USA. 
      etrachtenberg@chori.org
FAU - Vinson, M
AU  - Vinson M
FAU - Hayes, E
AU  - Hayes E
FAU - Hsu, Y-M
AU  - Hsu YM
FAU - Houtchens, K
AU  - Houtchens K
FAU - Erlich, H
AU  - Erlich H
FAU - Klitz, W
AU  - Klitz W
FAU - Hsia, Y
AU  - Hsia Y
FAU - Hollenbach, J
AU  - Hollenbach J
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20070927
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-DP Antigens)
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPB1 antigen)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*03:01 antigen)
RN  - 0 (HLA-DRB1*12:02 antigen)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - *Alleles
MH  - China
MH  - Ethnicity/*genetics
MH  - Gene Frequency
MH  - *Genetics, Population
MH  - Genotype
MH  - HLA-A Antigens/genetics
MH  - HLA-B Antigens/genetics
MH  - HLA-C Antigens/genetics
MH  - HLA-DP Antigens/genetics
MH  - HLA-DP beta-Chains
MH  - HLA-DQ Antigens/genetics
MH  - HLA-DQ alpha-Chains
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes/*genetics
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Humans
EDAT- 2007/09/29 09:00
MHDA- 2008/05/16 09:00
CRDT- 2007/09/29 09:00
PHST- 2007/09/29 09:00 [pubmed]
PHST- 2008/05/16 09:00 [medline]
PHST- 2007/09/29 09:00 [entrez]
AID - TAN932 [pii]
AID - 10.1111/j.1399-0039.2007.00932.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2007 Dec;70(6):455-63. doi: 10.1111/j.1399-0039.2007.00932.x. 
      Epub 2007 Sep 27.