PMID- 17900511
OWN - NLM
STAT- MEDLINE
DCOM- 20071206
LR  - 20211020
IS  - 1931-5244 (Print)
IS  - 1878-1810 (Linking)
VI  - 150
IP  - 4
DP  - 2007 Oct
TI  - Molecular classification of nodal metastasis in primary larynx squamous cell 
      carcinoma.
PG  - 233-45
AB  - Classification and prognosis of larynx squamous cell carcinoma (LSCC) depends on 
      clinical and histopathological examination. Currently, expression profiling 
      harbors the potential to investigate, classify, and better manage cancer. Gene 
      expression profiles of 22 primary LSCCs were analyzed by microarrays containing 
      19,200 cDNAs. GOAL functionally classified differentially expressed genes, and a 
      novel "in silico" procedure identified physical gene clusters differentially 
      transcribed. A signature of 158 genes differentiated tumors with nodal 
      metastasis. A novel statistical method allowed categorization of metastatic 
      tumors into 2 distinct subgroups of differential gene expression patterns. Among 
      genes correlated to nodal metastatic progression, we verified in vitro that 
      NM23-H3 reduced cell motility and TRIM8 were a growth suppressor. Six chromosomal 
      regions were specifically downregulated in metastatic tumors. This large-scale 
      gene expression analysis in LSCC provides information on changes in genomic 
      activity associated with lymphonodal metastasis and identifies molecules that 
      might prove useful as novel therapeutic targets.
FAU - Carinci, Francesco
AU  - Carinci F
AD  - Department of Maxillofacial Surgery, University of Ferrara, Ferrara, Italy.
FAU - Arcelli, Diego
AU  - Arcelli D
FAU - Lo Muzio, Lorenzo
AU  - Lo Muzio L
FAU - Francioso, Francesca
AU  - Francioso F
FAU - Valentini, Davide
AU  - Valentini D
FAU - Evangelisti, Rita
AU  - Evangelisti R
FAU - Volinia, Stefano
AU  - Volinia S
FAU - D'Angelo, Anna
AU  - D'Angelo A
FAU - Meroni, Germana
AU  - Meroni G
FAU - Zollo, Massimo
AU  - Zollo M
FAU - Pastore, Antonio
AU  - Pastore A
FAU - Ionna, Franco
AU  - Ionna F
FAU - Mastrangelo, Filiberto
AU  - Mastrangelo F
FAU - Conti, Pio
AU  - Conti P
FAU - Tete, Stefano
AU  - Tete S
LA  - eng
GR  - TGM06S01/TI_/Telethon/Italy
GR  - TGM06Z03/TI_/Telethon/Italy
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070523
PL  - United States
TA  - Transl Res
JT  - Translational research : the journal of laboratory and clinical medicine
JID - 101280339
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Carrier Proteins)
RN  - 0 (DNA, Complementary)
RN  - 0 (NM23 Nucleoside Diphosphate Kinases)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (RNA, Neoplasm)
RN  - 0 (TRIM8 protein, human)
RN  - 0 (Tumor Suppressor Proteins)
RN  - EC 2.7.4.6 (NME1 protein, human)
SB  - IM
MH  - Biomarkers, Tumor/*genetics
MH  - Carcinoma, Squamous Cell/*genetics/metabolism/pathology/*secondary
MH  - Carrier Proteins/*genetics
MH  - Cell Line, Tumor
MH  - Cluster Analysis
MH  - DNA, Complementary/genetics
MH  - Disease Progression
MH  - Down-Regulation/genetics
MH  - Gene Expression Profiling
MH  - *Gene Expression Regulation, Neoplastic
MH  - Genes, Neoplasm
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics/metabolism/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - NM23 Nucleoside Diphosphate Kinases/*genetics
MH  - Neoplasm Staging
MH  - Nerve Tissue Proteins/*genetics
MH  - Oligonucleotide Array Sequence Analysis/methods
MH  - Prognosis
MH  - RNA, Neoplasm/isolation & purification
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Tumor Suppressor Proteins/genetics
MH  - Up-Regulation/genetics
EDAT- 2007/09/29 09:00
MHDA- 2007/12/07 09:00
CRDT- 2007/09/29 09:00
PHST- 2006/11/22 00:00 [received]
PHST- 2007/03/12 00:00 [revised]
PHST- 2007/03/13 00:00 [accepted]
PHST- 2007/09/29 09:00 [pubmed]
PHST- 2007/12/07 09:00 [medline]
PHST- 2007/09/29 09:00 [entrez]
AID - S1931-5244(07)00096-5 [pii]
AID - 10.1016/j.trsl.2007.03.011 [doi]
PST - ppublish
SO  - Transl Res. 2007 Oct;150(4):233-45. doi: 10.1016/j.trsl.2007.03.011. Epub 2007 
      May 23.