PMID- 17901090
OWN - NLM
STAT- MEDLINE
DCOM- 20080805
LR  - 20161124
IS  - 1468-2060 (Electronic)
IS  - 0003-4967 (Linking)
VI  - 67
IP  - 7
DP  - 2008 Jul
TI  - Association between radiographic severity of rheumatoid arthritis and shared 
      epitope alleles: differing mechanisms of susceptibility and protection.
PG  - 980-3
AB  - OBJECTIVE: To investigate the association of a recently described classification 
      of Human leukocyte antigen (HLA)-DRB1 shared epitope alleles with rheumatoid 
      factors (RF) and anti-cyclic citrullinated peptide (CCP) production and 
      radiological severity in rheumatoid arthritis (RA). METHODS: Patients with RA (n 
      = 962) were studied. Genotyping of DRB1 alleles and assays for RF and anti-CCP 
      were performed. Radiological severity was measured using the modified Larsen 
      score. RESULTS: In accordance with previous reports, we found carriage of S2 
      alleles (K-R-A-A at positions 71-74) to be associated with more severe disease 
      with a gene-dose effect (p = 0.0059), and also associated with the presence of 
      anti-CCP and RF (p<0.001). Carriage of S1 alleles (D-E-R-A-A at positions 70-74) 
      was associated with less severe disease (p = 0.01), however there was no 
      association between S1 and either anti-CCP or RF, suggesting that the basis for 
      this possible protective effect was not related to autoantibody-producing B 
      cells. CONCLUSIONS: These data suggest that multiple biological mechanisms 
      underlie the DRB1 association with rheumatoid arthritis severity.
FAU - Mewar, D
AU  - Mewar D
AD  - School of Medicine and Biomedical Sciences, University of Sheffield, Beech Hill 
      Road, Sheffield, UK.
FAU - Marinou, I
AU  - Marinou I
FAU - Coote, A L
AU  - Coote AL
FAU - Moore, D J
AU  - Moore DJ
FAU - Akil, M
AU  - Akil M
FAU - Smillie, D
AU  - Smillie D
FAU - Dickson, M C
AU  - Dickson MC
FAU - Binks, M H
AU  - Binks MH
FAU - Montgomery, D S
AU  - Montgomery DS
FAU - Wilson, A G
AU  - Wilson AG
LA  - eng
PT  - Journal Article
DEP - 20070927
PL  - England
TA  - Ann Rheum Dis
JT  - Annals of the rheumatic diseases
JID - 0372355
RN  - 0 (Autoantibodies)
RN  - 0 (Epitopes)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Peptides, Cyclic)
RN  - 0 (cyclic citrullinated peptide)
RN  - 9009-79-4 (Rheumatoid Factor)
SB  - IM
MH  - Alleles
MH  - Arthritis, Rheumatoid/*diagnostic imaging/*genetics/immunology
MH  - Autoantibodies/blood
MH  - Epitopes/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Male
MH  - Peptides, Cyclic/immunology
MH  - Radiography
MH  - Rheumatoid Factor/blood
MH  - Severity of Illness Index
EDAT- 2007/09/29 09:00
MHDA- 2008/08/06 09:00
CRDT- 2007/09/29 09:00
PHST- 2007/09/29 09:00 [pubmed]
PHST- 2008/08/06 09:00 [medline]
PHST- 2007/09/29 09:00 [entrez]
AID - ard.2007.075382 [pii]
AID - 10.1136/ard.2007.075382 [doi]
PST - ppublish
SO  - Ann Rheum Dis. 2008 Jul;67(7):980-3. doi: 10.1136/ard.2007.075382. Epub 2007 Sep 
      27.