PMID- 17901861
OWN - NLM
STAT- MEDLINE
DCOM- 20071121
LR  - 20161124
IS  - 1234-1010 (Print)
IS  - 1234-1010 (Linking)
VI  - 13
IP  - 10
DP  - 2007 Oct
TI  - Recent advances in tumor hypoxia: tumor progression, molecular mechanisms, and 
      therapeutic implications.
PG  - RA175-80
AB  - Tumor oxygenation status is tightly regulated and correlates with its aggressive 
      behavior. Hypoxia plays critical roles in tumor progression including tumor 
      angiogenesis, mutation rate, metastasis and resistance to radiation and 
      chemotherapy. Many molecular pathways have been recognized to mediate these 
      hypoxia-induced responses in tumors. For example, extensive studies demonstrate 
      that hypoxia-inducible factor-1 (HIF-1) is a key molecule in regulating tumor 
      responses to hypoxia. Many other genes including growth factors, glycolytic 
      enzymes, cytokines, and transcription factors are inducible by hypoxia via either 
      HIF-1-dependent or HIF-1-independent pathways. This review summarizes current 
      advances in tumor hypoxia regarding new technologies of tumor hypoxia 
      measurement, clinical and animal studies, cell culture models, the 
      hypoxia-induced key molecules and therapeutic implications. This valuable 
      information is particularly timely and helpful for clinicians and researchers who 
      want to recognize the newest endeavors within the field and identify possible 
      lines of investigation in tumor hypoxia.
FAU - Zhang, Yuqing
AU  - Zhang Y
AD  - Michael E. DeBakey Department of Surgery, Molecular Surgeon Research Center, 
      Baylor College of Medicine, Houston, TX, USA.
FAU - Li, Min
AU  - Li M
FAU - Yao, Qizhi
AU  - Yao Q
FAU - Chen, Changyi
AU  - Chen C
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Med Sci Monit
JT  - Medical science monitor : international medical journal of experimental and 
      clinical research
JID - 9609063
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Animals
MH  - Disease Progression
MH  - Humans
MH  - Hypoxia/*pathology/*therapy
MH  - Neoplasms/metabolism/*pathology/*therapy
MH  - Oxygen/metabolism
MH  - Tumor Cells, Cultured
RF  - 48
EDAT- 2007/09/29 09:00
MHDA- 2007/12/06 09:00
CRDT- 2007/09/29 09:00
PHST- 2007/09/29 09:00 [pubmed]
PHST- 2007/12/06 09:00 [medline]
PHST- 2007/09/29 09:00 [entrez]
AID - 502434 [pii]
PST - ppublish
SO  - Med Sci Monit. 2007 Oct;13(10):RA175-80.