PMID- 17902094
OWN - NLM
STAT- MEDLINE
DCOM- 20071128
LR  - 20220408
IS  - 1365-2168 (Electronic)
IS  - 0007-1323 (Linking)
VI  - 94
IP  - 11
DP  - 2007 Nov
TI  - Randomized clinical trial of the effect of preoperative oral carbohydrate 
      treatment on postoperative whole-body protein and glucose kinetics.
PG  - 1342-50
AB  - BACKGROUND: Preoperative oral carbohydrate (CHO) reduces postoperative insulin 
      resistance. In this randomized trial, the effect of CHO on postoperative 
      whole-body protein turnover was studied. METHODS: Glucose and protein kinetics 
      ([6,6(2)H(2)]D-glucose, [(2)H(5)]phenylalanine, [(2)H(2)]tyrosine and 
      [(2)H(4)]tyrosine) and substrate oxidation (indirect calorimetry) were studied at 
      baseline and during hyperinsulinaemic normoglycaemic clamping before and on the 
      first day after colorectal resection. Fifteen patients were randomized to receive 
      a preoperative beverage with high (125 mg/ml) or low (25 mg/ml) CHO content. 
      RESULTS: Three patients were excluded after the intervention, leaving six 
      patients in each group. After surgery whole-body protein balance did not change 
      in the high oral CHO group, whereas it was more negative in the low oral CHO 
      group after surgery at baseline (P = 0.003) and during insulin stimulation (P = 
      0.005). Insulin-stimulated endogenous glucose release was similar before and 
      after surgery in the high oral CHO group, but was higher after surgery in the low 
      oral CHO group (P = 0.013) and compared with the high oral CHO group (P = 0.044). 
      CONCLUSION: Whole-body protein balance and the suppressive effect of insulin on 
      endogenous glucose release are better maintained when patients receive a CHO-rich 
      beverage before surgery.
CI  - Copyright (c) 2007 British Journal of Surgery Society Ltd.
FAU - Svanfeldt, M
AU  - Svanfeldt M
AD  - Division of Surgery, Karolinska Institute, Karolinska University Hospital 
      Huddinge, Sweden. monika.svanfeldt@karolinska.se
FAU - Thorell, A
AU  - Thorell A
FAU - Hausel, J
AU  - Hausel J
FAU - Soop, M
AU  - Soop M
FAU - Rooyackers, O
AU  - Rooyackers O
FAU - Nygren, J
AU  - Nygren J
FAU - Ljungqvist, O
AU  - Ljungqvist O
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Surg
JT  - The British journal of surgery
JID - 0372553
RN  - 0 (Carbohydrates)
RN  - 42HK56048U (Tyrosine)
RN  - 47E5O17Y3R (Phenylalanine)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Administration, Oral
MH  - Adult
MH  - Aged
MH  - Analysis of Variance
MH  - Calorimetry
MH  - Carbohydrates/administration & dosage/*pharmacology
MH  - Colonic Diseases/surgery
MH  - Female
MH  - Glucose/administration & dosage/*pharmacokinetics
MH  - Humans
MH  - Infusions, Intravenous
MH  - Male
MH  - Middle Aged
MH  - Phenylalanine/administration & dosage/*pharmacokinetics
MH  - Postoperative Period
MH  - Preoperative Care
MH  - Rectal Diseases/surgery
MH  - Tyrosine/administration & dosage/*pharmacokinetics
EDAT- 2007/09/29 09:00
MHDA- 2007/12/06 09:00
CRDT- 2007/09/29 09:00
PHST- 2007/09/29 09:00 [pubmed]
PHST- 2007/12/06 09:00 [medline]
PHST- 2007/09/29 09:00 [entrez]
AID - 10.1002/bjs.5919 [doi]
PST - ppublish
SO  - Br J Surg. 2007 Nov;94(11):1342-50. doi: 10.1002/bjs.5919.