PMID- 17904463
OWN - NLM
STAT- MEDLINE
DCOM- 20071030
LR  - 20220331
IS  - 1555-7162 (Electronic)
IS  - 0002-9343 (Linking)
VI  - 120
IP  - 10
DP  - 2007 Oct
TI  - Diagnostic evaluation of mononucleosis-like illnesses.
PG  - 911.e1-8
AB  - Clinicians face a diagnostic challenge when a patient with the classic fever, 
      pharyngitis, and lymphadenopathy triad of infectious mononucleosis has a negative 
      "spot" heterophile antibody test. This screening test, although commonly 
      considered sensitive for the presence of Epstein-Barr virus (EBV) infection, may 
      be negative early after infection. A growing number of pathogens have been 
      reported to cause heterophile-negative mononucleosis-like illnesses, including 
      cytomegalovirus (CMV), human herpesvirus 6 (HHV-6), human immunodeficiency virus 
      (HIV), adenovirus, herpes simplex virus (HSV), Streptococcus pyogenes, and 
      Toxoplasma gondii. Other infectious and noninfectious disorders also may present 
      in ways that mimic mononucleosis, but fail to generate EBV's archetypal triad of 
      clinical findings. A systematic approach to the diagnosis of mononucleosis-like 
      illnesses ensures that conditions warranting specific therapy are distinguished 
      from others requiring only supportive care.
FAU - Hurt, Christopher
AU  - Hurt C
AD  - Department of Medicine, Division of Infectious Diseases, University of North 
      Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC, USA.
FAU - Tammaro, Dominick
AU  - Tammaro D
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Am J Med
JT  - The American journal of medicine
JID - 0267200
RN  - 0 (Antibodies, Heterophile)
SB  - IM
MH  - Adenovirus Infections, Human/diagnosis
MH  - Adolescent
MH  - Adult
MH  - Algorithms
MH  - Antibodies, Heterophile/blood
MH  - Cytomegalovirus Infections/diagnosis
MH  - Diagnosis, Differential
MH  - HIV Infections/diagnosis
MH  - HIV-1
MH  - Herpes Simplex/diagnosis
MH  - Herpesvirus 1, Human
MH  - Herpesvirus 6, Human
MH  - Humans
MH  - Infectious Mononucleosis/blood/*diagnosis
MH  - Roseolovirus Infections/diagnosis
MH  - Sensitivity and Specificity
MH  - Streptococcal Infections/diagnosis
MH  - Streptococcus pyogenes
MH  - Toxoplasmosis/diagnosis
RF  - 60
EDAT- 2007/10/02 09:00
MHDA- 2007/10/31 09:00
CRDT- 2007/10/02 09:00
PHST- 2006/10/12 00:00 [received]
PHST- 2006/11/29 00:00 [revised]
PHST- 2006/12/01 00:00 [accepted]
PHST- 2007/10/02 09:00 [pubmed]
PHST- 2007/10/31 09:00 [medline]
PHST- 2007/10/02 09:00 [entrez]
AID - S0002-9343(07)00036-8 [pii]
AID - 10.1016/j.amjmed.2006.12.011 [doi]
PST - ppublish
SO  - Am J Med. 2007 Oct;120(10):911.e1-8. doi: 10.1016/j.amjmed.2006.12.011.