PMID- 17905422
OWN - NLM
STAT- MEDLINE
DCOM- 20080409
LR  - 20211020
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 88
IP  - 3
DP  - 2008 Jan
TI  - Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): possible mediation by 
      serotonin 5-HT1A and 5-HT2A receptors in rodents.
PG  - 358-65
AB  - N,N-dipropyltryptamine (DPT) is a synthetic tryptamine hallucinogen which has 
      been used psychotherapeutically in humans, but has been studied preclinically 
      only rarely. In the present studies, DPT was tested in a drug-elicited 
      head-twitch assay in mice, and in rats trained to discriminate lysergic acid 
      diethylamide (LSD), N,N-dimethyl-4-phosphoryloxytryptamine (psilocybin), or 
      3,4-methylenedioxymethamphetamine (MDMA). A separate group of rats was also 
      trained to recognize DPT itself as a discriminative stimulus, and in all cases, 
      the behavioral effects of DPT were challenged with the selective serotonin 
      (5-HT)2A antagonist M100907, the 5-HT1A selective antagonist WAY-100635, or their 
      combination. In the head-twitch assay, DPT elicited dose-dependent effects, 
      producing a biphasic dose-effect curve. WAY-100635 produced a parallel rightward 
      shift in the dose-effect curve for head twitches, indicative of surmountable 
      antagonism, but the antagonist effects of M100907 were functionally 
      insurmountable. DPT produced partial to full substitution when tested in rats 
      trained to discriminate LSD, psilocybin or MDMA, and served as a discriminative 
      stimulus. In all cases, the antagonist effects of M100907 were more profound than 
      were those of WAY-100635. DPT is thus active in two rodent models relevant to 
      5-HT2 agonist activity. The effectiveness with which M100907 antagonizes the 
      behavioral actions of this compound strongly suggest that the 5-HT2A receptor is 
      an important site of action for DPT, but the modulatory actions of WAY-100635 
      also imply a 5-HT1A-mediated component to the actions of this compound.
FAU - Fantegrossi, William E
AU  - Fantegrossi WE
AD  - Division of Neuroscience, Yerkes National Primate Research Center, 954 Gatewood 
      Road, Atlanta, GA 30322, USA. wfanteg@emory.edu <wfanteg@emory.edu>
FAU - Reissig, Chad J
AU  - Reissig CJ
FAU - Katz, Elyse B
AU  - Katz EB
FAU - Yarosh, Haley L
AU  - Yarosh HL
FAU - Rice, Kenner C
AU  - Rice KC
FAU - Winter, Jerrold C
AU  - Winter JC
LA  - eng
GR  - F31 DA016457/DA/NIDA NIH HHS/United States
GR  - R01 DA003385/DA/NIDA NIH HHS/United States
GR  - R21 DA020645-02/DA/NIDA NIH HHS/United States
GR  - R56 DA003385/DA/NIDA NIH HHS/United States
GR  - R21 DA020645/DA/NIDA NIH HHS/United States
GR  - DA020645/DA/NIDA NIH HHS/United States
GR  - DA016457/DA/NIDA NIH HHS/United States
GR  - DA03385/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20070914
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Fluorobenzenes)
RN  - 0 (Hallucinogens)
RN  - 0 (Piperazines)
RN  - 0 (Piperidines)
RN  - 0 (Pyridines)
RN  - 0 (Receptor, Serotonin, 5-HT2A)
RN  - 0 (Serotonin Antagonists)
RN  - 0 (Tryptamines)
RN  - 112692-38-3 (Receptor, Serotonin, 5-HT1A)
RN  - 2RV7212BP0 (Psilocybin)
RN  - 61-52-9 (dipropyltryptamine)
RN  - 71IH826FEG 
      (N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide)
RN  - 8NA5SWF92O (Lysergic Acid Diethylamide)
RN  - EW71EE171J (volinanserin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Data Interpretation, Statistical
MH  - Discrimination Learning/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Fluorobenzenes/pharmacology
MH  - *Hallucinogens
MH  - Lysergic Acid Diethylamide/pharmacology
MH  - Male
MH  - Mice
MH  - N-Methyl-3,4-methylenedioxyamphetamine/pharmacology
MH  - Piperazines/pharmacology
MH  - Piperidines/pharmacology
MH  - Psilocybin/pharmacology
MH  - Pyridines/pharmacology
MH  - Rats
MH  - Rats, Inbred F344
MH  - Receptor, Serotonin, 5-HT1A/*drug effects
MH  - Receptor, Serotonin, 5-HT2A/*drug effects
MH  - Serotonin Antagonists/pharmacology
MH  - Tryptamines/*pharmacology
PMC - PMC2322878
MID - NIHMS38656
EDAT- 2007/10/02 09:00
MHDA- 2008/04/10 09:00
PMCR- 2009/01/01
CRDT- 2007/10/02 09:00
PHST- 2007/05/11 00:00 [received]
PHST- 2007/09/06 00:00 [revised]
PHST- 2007/09/07 00:00 [accepted]
PHST- 2007/10/02 09:00 [pubmed]
PHST- 2008/04/10 09:00 [medline]
PHST- 2007/10/02 09:00 [entrez]
PHST- 2009/01/01 00:00 [pmc-release]
AID - S0091-3057(07)00289-4 [pii]
AID - 10.1016/j.pbb.2007.09.007 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2008 Jan;88(3):358-65. doi: 10.1016/j.pbb.2007.09.007. 
      Epub 2007 Sep 14.