PMID- 17906642
OWN - NLM
STAT- MEDLINE
DCOM- 20071011
LR  - 20220409
IS  - 1474-1784 (Electronic)
IS  - 1474-1776 (Linking)
VI  - 6
IP  - 10
DP  - 2007 Oct
TI  - RAR and RXR modulation in cancer and metabolic disease.
PG  - 793-810
AB  - Retinoic acid receptors (RARs) are ligand-controlled transcription factors that 
      function as heterodimers with retinoid X receptors (RXRs) to regulate cell growth 
      and survival. The success of RAR modulation in the treatment of acute 
      promyelocytic leukaemia (APL) has stimulated considerable interest in the 
      development of RAR and RXR modulators. This has been aided by recent advances in 
      the understanding of the biological role of RARs and RXRs and in the design of 
      selective receptor modulators that might overcome the limitations of current 
      drugs. Here, we discuss the challenges and opportunities for therapeutic 
      strategies based on RXR and RAR modulators, with a focus on cancer and metabolic 
      diseases such as diabetes and obesity.
FAU - Altucci, Lucia
AU  - Altucci L
AD  - Dipartimento di Patologia Generale, Seconda Universita degli Studi di Napoli, 
      Vico Luigi de Crecchio 7, 80138 Napoli, Italy.
FAU - Leibowitz, Mark D
AU  - Leibowitz MD
FAU - Ogilvie, Kathleen M
AU  - Ogilvie KM
FAU - de Lera, Angel R
AU  - de Lera AR
FAU - Gronemeyer, Hinrich
AU  - Gronemeyer H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Nat Rev Drug Discov
JT  - Nature reviews. Drug discovery
JID - 101124171
RN  - 0 (Ligands)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Retinoids)
SB  - IM
MH  - Clinical Trials as Topic
MH  - Diabetes Mellitus/*drug therapy/metabolism
MH  - Humans
MH  - Ligands
MH  - Neoplasms/*drug therapy/metabolism
MH  - Obesity/*drug therapy/metabolism
MH  - Receptors, Retinoic Acid/agonists/antagonists & inhibitors/*metabolism
MH  - Retinoid X Receptors/agonists/antagonists & inhibitors/metabolism
MH  - *Retinoids/chemical synthesis/chemistry/therapeutic use
RF  - 184
EDAT- 2007/10/02 09:00
MHDA- 2007/10/12 09:00
CRDT- 2007/10/02 09:00
PHST- 2007/10/02 09:00 [pubmed]
PHST- 2007/10/12 09:00 [medline]
PHST- 2007/10/02 09:00 [entrez]
AID - nrd2397 [pii]
AID - 10.1038/nrd2397 [doi]
PST - ppublish
SO  - Nat Rev Drug Discov. 2007 Oct;6(10):793-810. doi: 10.1038/nrd2397.