PMID- 17906978
OWN - NLM
STAT- MEDLINE
DCOM- 20080225
LR  - 20131121
IS  - 1438-2199 (Electronic)
IS  - 0939-4451 (Linking)
VI  - 34
IP  - 1
DP  - 2008 Jan
TI  - Relationships between the sedative and hypnotic effects of 
      intracerebroventricular administration of L-serine and its metabolites, pyruvate 
      and the derivative amino acids contents in the neonatal chicks under acute 
      stressful conditions.
PG  - 55-60
AB  - Intracerebroventricular (i.c.v.) injection of L-serine was shown to have sedative 
      and hypnotic effects on neonatal chicks under acute stressful conditions. To 
      clarify the central mechanism of these effects of L-serine, two experiments were 
      done. First, we focused on the glycogenic pathway in which L-serine is converted 
      into pyruvate and finally glucose. I.c.v. administration of pyruvate (0.84 
      micromol) did not induce any behavioral and endocrinological changes, while 
      L-serine and glucose triggered sedative and hypnotic effects. Secondly, the 
      relationship between the sedation by L-serine and the metabolism into other amino 
      acids which have sedative effects was investigated in the telencephalon and 
      diencephalon. In both brain areas, a dose-dependent increase was seen in 
      L-serine, although other amino acids were not changed. In the present study, it 
      was concluded that the sedative action of L-serine was not due to the action of 
      its metabolite pyruvate, or to the action of other amino acids.
FAU - Asechi, M
AU  - Asechi M
AD  - Laboratory of Advanced Animal and Marine Bioresources, Graduate School of 
      Bioresources and Bioenvironmental Sciences, Kyushu University, Fukuoka, Japan.
FAU - Kurauchi, I
AU  - Kurauchi I
FAU - Tomonaga, S
AU  - Tomonaga S
FAU - Yamane, H
AU  - Yamane H
FAU - Suenaga, R
AU  - Suenaga R
FAU - Tsuneyoshi, Y
AU  - Tsuneyoshi Y
FAU - Denbow, D M
AU  - Denbow DM
FAU - Furuse, M
AU  - Furuse M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071002
PL  - Austria
TA  - Amino Acids
JT  - Amino acids
JID - 9200312
RN  - 0 (Amino Acids)
RN  - 0 (Hypnotics and Sedatives)
RN  - 8558G7RUTR (Pyruvic Acid)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Amino Acids/*administration & dosage/chemistry/metabolism/pharmacology
MH  - Animals
MH  - Animals, Newborn
MH  - Chickens
MH  - Glucose/administration & dosage/pharmacology
MH  - Hypnotics and Sedatives/*administration & 
      dosage/chemistry/metabolism/pharmacology
MH  - Injections
MH  - Male
MH  - Molecular Structure
MH  - Pyruvic Acid/*administration & dosage/chemistry/metabolism/pharmacology
MH  - Time Factors
EDAT- 2007/10/02 09:00
MHDA- 2008/02/26 09:00
CRDT- 2007/10/02 09:00
PHST- 2007/04/10 00:00 [received]
PHST- 2007/07/26 00:00 [accepted]
PHST- 2007/10/02 09:00 [pubmed]
PHST- 2008/02/26 09:00 [medline]
PHST- 2007/10/02 09:00 [entrez]
AID - 10.1007/s00726-007-0596-y [doi]
PST - ppublish
SO  - Amino Acids. 2008 Jan;34(1):55-60. doi: 10.1007/s00726-007-0596-y. Epub 2007 Oct 
      2.