PMID- 17907112
OWN - NLM
STAT- MEDLINE
DCOM- 20080226
LR  - 20151119
IS  - 1479-1641 (Print)
IS  - 1479-1641 (Linking)
VI  - 4
IP  - 3
DP  - 2007 Sep
TI  - Effect of glucose-insulin-potassium (GIK) infusion on biomarkers of 
      cardiovascular risk in ST elevation myocardial infarction (STEMI): insight into 
      the failure of GIK.
PG  - 222-5
AB  - Glucose-insulin-potassium (GIK) infusion favourably affects several biomarkers 
      associated with risk in the setting of myocardial infarction (MI). In the context 
      of a recent trial demonstrating no benefit of GIK, we assessed the impact of GIK 
      on inflammation, neurohormonal activation and myonecrosis in ST elevation 
      myocardial infarction (STEMI). In a local substudy of an international randomised 
      trial, 25 patients with STEMI were randomised to receive a 24-hour infusion of 
      GIK vs. no GIK. C-reactive protein (hs-CRP), N-terminal pro-brain natriuretic 
      peptide (NT-proBNP) and troponin T (TnT) were assayed at baseline and at 24 
      hours. The two groups were well matched for baseline characteristics and infarct 
      location. There were no statistically significant differences at baseline or at 
      24 hours in levels of hs-CRP, NT-proBNP or cTnT, with similar and significant 
      increases in all three biomarkers by 24 hours in both groups. In conclusion, GIK 
      had no discernible effect on biomarkers associated with inflammation, 
      neurohormonal activation or myonecrosis, three pathways associated with adverse 
      outcomes in STEMI.
FAU - Parikh, Shailja V
AU  - Parikh SV
AD  - Department of Internal Medicine, the University of Texas Southwestern Medical 
      Center in Dallas, Texas 75235-9047, USA.
FAU - Abdullah, Shuaib M
AU  - Abdullah SM
FAU - Keeley, Ellen C
AU  - Keeley EC
FAU - Cigarroa, Joaquin E
AU  - Cigarroa JE
FAU - Addo, Tayo A
AU  - Addo TA
FAU - Warner, John J
AU  - Warner JJ
FAU - Khera, Amit
AU  - Khera A
FAU - de Lemos, James A
AU  - de Lemos JA
FAU - McGuire, Darren K
AU  - McGuire DK
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - England
TA  - Diab Vasc Dis Res
JT  - Diabetes & vascular disease research
JID - 101234011
RN  - 0 (Biomarkers)
RN  - 0 (Insulin)
RN  - 0 (Peptide Fragments)
RN  - 0 (glucose-insulin-potassium cardioplegic solution)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - IY9XDZ35W2 (Glucose)
RN  - RWP5GA015D (Potassium)
SB  - IM
MH  - Biomarkers/blood
MH  - C-Reactive Protein/analysis
MH  - Electrocardiography
MH  - Glucose/therapeutic use
MH  - Humans
MH  - Insulin/therapeutic use
MH  - Myocardial Infarction/blood/diagnosis/*drug therapy
MH  - Natriuretic Peptide, Brain/blood
MH  - Peptide Fragments/blood
MH  - Potassium/therapeutic use
MH  - Time Factors
MH  - Treatment Failure
EDAT- 2007/10/02 09:00
MHDA- 2008/02/27 09:00
CRDT- 2007/10/02 09:00
PHST- 2007/10/02 09:00 [pubmed]
PHST- 2008/02/27 09:00 [medline]
PHST- 2007/10/02 09:00 [entrez]
AID - 2827 [pii]
AID - 10.3132/dvdr.2007.043 [doi]
PST - ppublish
SO  - Diab Vasc Dis Res. 2007 Sep;4(3):222-5. doi: 10.3132/dvdr.2007.043.